One Less Painful Procedure: Using Umbilical Cord Blood as Alternative Source to Admission Complete Blood Count

Prakash, Neera; DeCristofaro, Joseph D.; Maduekwe, Echezona T.

doi:10.1055/s-0037-1601565

Cited by 15 publications

(14 citation statements)

References 24 publications

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“…UCB is often used as surrogate for newborn blood, 38, 39 however, there may be key differences in antibody transfer into cord blood and fetal circulation. Therefore, we next assessed RBD-specific IgG titers in newborn blood.…”

Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

Marshall

Blanton

Doratt

et al. 2022

Preprint

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BackgroundInfection during pregnancy can result in adverse outcomes for both pregnant persons and offspring. Maternal vaccination is an effective mechanism to protect both mother and neonate into post-partum. However, our understanding of passive transfer of antibodies elicited by maternal SARS-CoV-2 mRNA vaccination during pregnancy remains incomplete.ObjectiveWe aimed to evaluate the antibody responses engendered by maternal SARS-CoV-2 vaccination following initial and booster doses in maternal circulation and breastmilk to better understand passive immunization of the newborn.Study DesignWe collected longitudinal blood samples from 121 pregnant women who received SARS-CoV-2 mRNA vaccines spanning from early gestation to delivery followed by collection of blood samples and breastmilk between delivery and 12 months post-partum. During the study, 70% of the participants also received a booster post-partum. Paired maternal plasma, breastmilk, umbilical cord plasma, and newborn plasma samples were tested via enzyme-linked immunosorbent assays (ELISA) to evaluate SARS-CoV-2 specific IgG antibody levels.ResultsVaccine-elicited maternal antibodies were detected in both cord blood and newborn blood, albeit at lower levels than maternal circulation, demonstrating transplacental passive immunization. Booster vaccination significantly increased spike specific IgG antibody titers in maternal plasma and breastmilk. Finally, SARS-CoV-2 specific IgG antibodies in newborn blood correlated negatively with days post initial maternal vaccine dose.ConclusionVaccine-induced maternal SARS-CoV-2 antibodies were passively transferred to the offspringin uterovia the placenta and after birth via breastfeeding. Maternal booster vaccination, regardless of gestational age at maternal vaccination, significantly increased antibody levels in breastmilk and maternal plasma, indicating the importance of this additional dose to maximize passive protection against SARS-CoV-2 infection for neonates and infants until vaccination eligibility.

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Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

Marshall

Blanton

Doratt

et al. 2022

Preprint

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“…In addition, there are also few reports comparing umbilical cord and venous blood results. 4,[6][7][8] In our study, reference intervals were determined for hematological parameters with CBC results from umbilical cord blood, and comparisons were made with venous blood results. In this way, it is examined whether it is necessary to determine the reference intervals for umbilical cord blood.…”

Section: Discussionmentioning

confidence: 99%

“…For these reasons, some studies have been conducted on whether or not to use umbilical cord blood instead of venous blood for CBC in newborns. 4,5 There is no risk of complications since umbilical cord blood is taken by a non-invasive method for the newborn. However, it is still being investigated whether the CBC with umbilical cord blood can provide reliable information as much as venous blood.…”

Section: Introductionmentioning

confidence: 99%

Reference intervals for complete blood count from Umbilical Cord Blood in newborns and comparison with Venous Blood Values

Gündüz

Temel

2021

Pak J Med Sci

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Background and Objective: Umbilical cord blood which can be obtained by a non-invasive method can be informative about the clinical status of the newborn. It was aimed to establish reference intervals for umbilical cord blood parameters, and to compare complete blood count results between umbilical cord and venous blood samples in this study. Methods: This study was conducted at Medipol University Sefaköy Hospital, Department of Pediatrics, Istanbul, Turkey. A total of 1898 newborns who were born in a two-year period between January 2018 and December 2019 were included in the study. Venous blood samples were taken from 184 of them, and umbilical cord blood samples were taken from 1714 newborns. Results: The percentiles were determined according to gender and delivery method for the hematological parameters of umbilical cord blood. While mean platelet, eosinophil and mean corpuscular volume values were similar between the groups (p>0.05 for each), and significant differences were found between the groups in terms of all other mean hematological parameters (p<0.05 for each). Conclusion: The results of the complete blood count of umbilical cord blood samples can provide reliable information about the newborn. There are significant differences between umbilical cord and venous blood samples in terms of hematological parameters. For these reasons, it is necessary to determine reliable value ranges for umbilical cord blood hematological parameters in newborns. Data of our study can be a guide for further studies and clinicians. doi: https://doi.org/10.12669/pjms.37.2.2526 How to cite this:Gunduz M, Temel H. Reference intervals for complete blood count from Umbilical Cord Blood in newborns and comparison with Venous Blood Values. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2526 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…The majority of infants requiring laboratory evaluations do not have easy access via umbilical lines and require phlebotomy by direct venous/arterial puncture or heel sticks [17]. These procedures are presumed to be painful for infants.…”

Section: Introductionmentioning

confidence: 99%

The Novel Use of Umbilical Cord Blood to Obtain Complete Blood Counts for Critical Neonatal Assessment

Hansen¹,

Haischer-Rollo²,

Shapiro³

et al. 2022

Cureus

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Background: Neonates undergoing clinical evaluations are often subjected to potentially painful phlebotomy for laboratory tests. The use of cord blood laboratory values for admission has been suggested as a means to decrease the risk of painful venipuncture and anemia.Methods: Peripheral and umbilical cord blood complete blood count (CBC) results were obtained from infants who required a CBC. Results were compared using the Sysmex XN heme analyzer (Sysmex, Kobe, Japan).Results: White blood cell (WBC) and hemoglobin (HgB) values were significantly higher in peripheral samples than in cord samples. The mean cord WBC count was 14.1 × 10 3 /mm 3 versus 15.6 × 10 3 /mm 3 peripherally (p < 0.001). The mean cord HgB was 15.8 g/dL versus 16.8 g/dL peripherally (p < 0.001). Cord platelet (Plt) counts were, conversely, lower in peripheral samples than in cord samples (264.8 × 10 3 /mm 3 versus 242.3 × 10 3 /mm 3 , respectively; p < 0.001). Although statistically different, the mean CBC values from both samples were within the reference ranges. Delayed cord clamping (DCC) increased peripheral versus cord HgB difference nearly threefold (0.6-1.7 g/dL; p = 0.01).Conclusions: Cord blood is an acceptable source for CBC blood sampling in newborn infants and can be used for clinical decisions. CBC laboratory values for cord blood remained within the peripheral blood reference range, with slight variability between the two samples.

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One Less Painful Procedure: Using Umbilical Cord Blood as Alternative Source to Admission Complete Blood Count

Cited by 15 publications

References 24 publications

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

Reference intervals for complete blood count from Umbilical Cord Blood in newborns and comparison with Venous Blood Values

The Novel Use of Umbilical Cord Blood to Obtain Complete Blood Counts for Critical Neonatal Assessment

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