One minute sit‐to‐stand test is an alternative to 6MWT to measure functional exercise performance in COPD patients

Reychler, Grégory; Boucard, Eliott; Péran, Loïc; Pichon, Romain; Ber-Moy, Catherine Le; Ouksel, H.; Liistro, Giuseppe; Chambellan, Arnaud; Beaumont, Marc

doi:10.1111/crj.12658

Cited by 100 publications

(90 citation statements)

References 56 publications

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“…Our results show that patients with moderate-to-severe ILD (FVC 85% ± 19%, DLco 51% ± 19%) performed a mean of 21 ± 6 repetitions during the 1STST, which is similar to the number of repetitions by age-matched COPD populations. 18 – 20 The number of repetitions performed during the 1STST in our study correlated poorly with the 6MWT distance. Previous work has shown that exercise capacity in the 6MWT and 1STST is affected by various anthropometric characteristics, pulmonary rehabilitation, and, potentially, by steroid-induced muscle dysfunction.…”

Section: Discussionmentioning

confidence: 55%

“… 16 The 1STST requires only a chair and is easy to perform, making it feasible for use in the physician’s office. 17 Studies to date have shown the 1STST to be well tolerated, sensitive, and reproducible in chronic obstructive pulmonary disease (COPD) 16 , 18 – 20 and cystic fibrosis 21 patients. However, its validity has never been investigated in ILD patients.…”

Section: Introductionmentioning

confidence: 99%

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The 1-minute sit-to-stand test to detect exercise-induced oxygen desaturation in patients with interstitial lung disease

Briand

Behal

Chenivesse

et al. 2018

Ther Adv Respir Dis

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Background:Although the 6-min walk test (6MWT) is the gold standard for assessing exercise-induced impairment of gas exchange, it cannot easily be performed in a clinical office environment. The aim of this study was to compare the 1-min sit-to-stand test (1STST) with the 6MWT for the ability to assess exercise-induced oxygen desaturation in patients with interstitial lung diseases (ILDs).Methods:A total of 107 patients were enrolled and classified into three groups: sarcoidosis, fibrotic idiopathic interstitial pneumonia (f-IIP), and other forms of ILD. The 6MWT and 1STST were performed on the same day, and pulmonary function tests, pulse oxygen saturation (SpO2), and dyspnea and fatigue (modified Borg scale) were assessed. SpO2 desaturation was evaluated by intraclass correlation coefficient (ICC), Bland–Altman analysis, and kappa (κ) coefficient in the whole population and the patient subgroups.Results:The SpO2 nadir during the 1STST and 6MWT showed good consistency [mean ± standard deviation: 92.5% ± 5% and 90% ± 7%, respectively; ICC 0.77, 95% confidence interval (CI) 0.71–0.83] and correlated strongly (r = 0.9, p < 0.0001). The frequency of patients with oxygen desaturation ⩾4% was also consistent for the two exercise tests (κ = 0.68, 95% CI 0.54–0.82). The number of repetitions in the 1STST correlated with the 6MWT distance (r = 0.5, p < 0.0001), but the dyspnea scores were higher during the 1STST than the 6MWT (p < 0.0001). These findings did not differ for the three patient subgroups.Conclusion:The 1STST can measure exercise-induced desaturation in ILD patients and could be used as an alternative test to the 6MWT in office practice.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The 1-minute sit-to-stand test to detect exercise-induced oxygen desaturation in patients with interstitial lung disease

Briand

Behal

Chenivesse

et al. 2018

Ther Adv Respir Dis

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“…Beyond walking or cycling tests, it would be also important to consider the 1-min sit-to-stand-test as an easily implementable measure of daily functional capacity in CRD. Indeed, this test reflects a movement frequently performed in daily life and has recently received increasing attention in CRD (Gruet et al, 2016b ; Radtke et al, 2016 ; Reychler et al, 2017 ) with a specific multicenter validation in COPD (Crook et al, 2017 ), making it an interesting correlate of real-world performance. The next key question is now to identify the ideal performance fatigability test which should ideally serve both research and clinical purposes.…”

Section: Performance Fatigability: Translation To Performance and Rehmentioning

confidence: 99%

Fatigue in Chronic Respiratory Diseases: Theoretical Framework and Implications For Real-Life Performance and Rehabilitation

Gruet

2018

Front. Physiol.

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Fatigue is a primary disabling symptom in chronic respiratory diseases (CRD) with major clinical implications. However, fatigue is not yet sufficiently explored and is still poorly understood in CRD, making this symptom underdiagnosed and undertreated in these populations. Fatigue is a dynamic phenomenon, particularly in such evolving diseases punctuated by acute events which can, alone or in combination, modulate the degree of fatigue experienced by the patients. This review supports a comprehensive inter-disciplinary approach of CRD-related fatigue and emphasizes the need to consider both its performance and perceived components. Most studies in CRD evaluated perceived fatigue as a trait characteristic using multidimensional scales, providing precious information about its prevalence and clinical impact. However, these scales are not adapted to understand the complex dynamics of fatigue in real-life settings and should be augmented with ecological assessment of fatigue. The state level of fatigue must also be considered during physical tasks as severe fatigue can emerge rapidly during exercise. CRD patients exhibit alterations in both peripheral and central nervous systems and these abnormalities can be exacerbated during exercise. Laboratory tests are necessary to provide mechanistic insights into how and why fatigue develops during exercise in CRD. A better knowledge of the neurophysiological mechanisms underlying perceived and performance fatigability and their influence on real-life performance will enable the development of new individualized countermeasures. This review aims first to shed light on the terminology of fatigue and then critically considers the contemporary models of fatigue and their relevance in the particular context of CRD. This article then briefly reports the prevalence and clinical consequences of fatigue in CRD and discusses the strengths and weaknesses of various fatigue scales. This review also provides several arguments to select the ideal test of performance fatigability in CRD and to translate the mechanistic laboratory findings into the clinical practice and real-world performance. Finally, this article discusses the dose-response relationship to training and the feasibility and validity of using the fatigue produced during exercise training sessions in CRD to optimize exercise training efficiency. Methodological concerns, examples of applications in selected diseases and avenues for future research are also provided.

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“…5 The 6MWT and 1-min STS measure different aspects of exercise capacity, but both tests yield significant correlations with knee extensor muscle strength. 6 In individuals with COPD, cystic fibrosis, and interstitial lung disease, moderate to strong correlations between both tests and knee extensor strength have been reported, 3,7,8 indicating that the 1-min STS could be a simple tool to assess functional capacity, particularly in settings where a 6MWT cannot be performed. To date, the 1-min STS has not been compared to the 6MWT in the heterogeneous population of lung transplantation candidates with end-stage pulmonary disease and peripheral muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

The 1-Minute Sit-to-Stand Test in Lung Transplant Candidates: An Alternative to the 6-Minute Walk Test

2019

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BACKGROUND: The 6-min walk test (6MWT) is a well-established functional exercise capacity test in lung transplant candidates. This study aimed to investigate the construct validity of the 1-min sit-to-stand test (1-min STS) as a marker of exercise capacity and knee extensor strength in lung transplantation candidates. METHODS: We retrospectively analyzed data from consecutive subjects referred for lung transplantation evaluation to our institution between 2015 and 2018. RESULTS: 38 subjects were included. We found strong correlations between the normalized 1-min STS and 6MWT (r ‫؍‬ 0.79, P < .001) and moderate correlations between 1-min STS and knee extensor strength (r ‫؍‬ 0.53, P ‫؍‬ .001) and between 6MWT and knee extensor strength (r ‫؍‬ 0.44, P ‫؍‬ .008). The 1-min STS elicited greater dyspnea (P ‫؍‬ .008) and lower oxygen desaturation compared to the 6MWT (P < .001). CONCLUSIONS: The 1-min STS is a valid functional exercise capacity test in lung transplantation candidates. Due to its ease of application, clinical practitioners may consider using the 1-min STS in situations when the 6MWT cannot be performed. Our pilot study may stimulate future research, including a head-to-head comparison between the 6MWT and 1-min STS in a large patient cohort including post-lung transplantation-monitoring.

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One minute sit‐to‐stand test is an alternative to 6MWT to measure functional exercise performance in COPD patients

Abstract: The one minute sit-to-stand test is a valuable alternative to 6MWT to estimate functional exercise performance in COPD patients. The cardiorespiratory demand is different between both tests although the variation of dypsnea is similar. No learning effect was observed for STST.

Cited by 100 publications

References 56 publications

The 1-minute sit-to-stand test to detect exercise-induced oxygen desaturation in patients with interstitial lung disease

The 1-minute sit-to-stand test to detect exercise-induced oxygen desaturation in patients with interstitial lung disease

Fatigue in Chronic Respiratory Diseases: Theoretical Framework and Implications For Real-Life Performance and Rehabilitation

The 1-Minute Sit-to-Stand Test in Lung Transplant Candidates: An Alternative to the 6-Minute Walk Test

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