2017
DOI: 10.1039/c7py01470h
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One-pot and gram-scale synthesis of biodegradable polyglycerols under ambient conditions: nanocarriers for intradermal drug delivery

Abstract: Biodegradable and biocompatible hyperbranched polymers are synthesized and their potential for dermal drug delivery is investigated.

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Cited by 27 publications
(46 citation statements)
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“…Hyperbranched PG‐ co ‐PCL copolymer (1) was synthesized by Haag et al according to previously published report . Briefly, copolymerization of the monomer mixture composed of glycidol and ε‐caprolactone was carried out in the presence of catalytic amount of tin octoate, at 50 °C.…”
Section: Methodsmentioning
confidence: 99%
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“…Hyperbranched PG‐ co ‐PCL copolymer (1) was synthesized by Haag et al according to previously published report . Briefly, copolymerization of the monomer mixture composed of glycidol and ε‐caprolactone was carried out in the presence of catalytic amount of tin octoate, at 50 °C.…”
Section: Methodsmentioning
confidence: 99%
“…Briefly, copolymerization of the monomer mixture composed of glycidol and ε‐caprolactone was carried out in the presence of catalytic amount of tin octoate, at 50 °C. Full chemical characterization of the compound has been described elsewhere . For this particular work, hyperbranched PG‐ co ‐PCL copolymer with a molecular weight of 14 kDa was used.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Glycidol and ε-caprolactone were initially copolymerized (50 • C, 4:1 Gld:CL molar ratio, Sn(Oct) 2 ), and sulfation of the copolymers was performed in the presence of sulfur trioxide pyridine complex (1.5 eq/OH groups), in dry DMF, at 60 • C (Scheme 14a). The molecular weight of the copolymers could be controlled by tuning the polymerization conditions, the monomer to catalyst ratio, as well as the stirring and the time of the polymerization [227]. Compared to dendritic polyglycerol sulfate (dPGS), these sulfated copolymers had hydrolysable ester bonds and were biocompatible, while they exhibited a significant lower influence on blood coagulation and a higher inhibition of complement activity than heparin.…”
Section: Functionalized Polyglycerol/poly(ε-caprolactone) Copolymersmentioning
confidence: 99%
“…Copolymerization of glycidol with other monomers results in a variety of macromolecules with a combination of useful physicochemical properties. For example, the nondegradable feature of polyglycerols, which hamper their in vivo applications, has been overcome by incorporating degradable oligomers into their backbone . Among lactones, γ‐butyrolactone (γ‐BL) is a low‐strained five‐membered, lactone ring with high stability, and low chemical reactivity.…”
Section: Introductionmentioning
confidence: 99%