One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions

Abstract

A series of 11-aryl-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.

Recent advances in the multicomponent synthesis of heterocycles using tetronic acid

“…Utilizing fractions of tetracyclic amines, pyridine, and furan, this method offers the advantages of operational simplicity and avoids the necessity for separate intermediates in the reaction. 39 2.6. Dihydrofuro [3,4-b]quinoline Laurentiz et al, have developed a straightforward and efficient method for synthesizing dihydroquinoline lactone derivatives (19).…”

“…Utilizing fractions of tetracyclic amines, pyridine, and furan, this method offers the advantages of operational simplicity and avoids the necessity for separate intermediates in the reaction. 39…”