One-pot and two-step synthesis of novel carbonylthioureas and dicarbonyldithioureas derivatives

Banaei, Alireza; Shiran, Jafar Abbasi; Saadat, Afshin; Ardabili, Farnaz Fazlalizadeh; McArdle, Patrick

doi:10.1016/j.molstruc.2015.06.074

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…The compounds showed superior antibacterial activity towards Salmonella enterica and Micrococcus luteus compared with Bacillus subtilis and Pseudomonas aeruginosa. Among the series, m-hydroxy derivatives were the most potent and a simple reason is that the OH-group is highly polar causing a strong interaction of the compound with the bacterium cell wall [151].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

et al. 2016

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1-(Acyl/aroyl)-3-(substituted)thioureas are privileged architectures that have received remarkable attention of researchers in view of their variable topological aspects, binding modes and broad spectrum promising pharmacological properties. Reactivity of acyl thiourea derivatives has presented various organic transformations into other demanding scaffolds and this is an attractive strategy for synthetic chemists to access heterocyclic cores. Multiple binding sites make them flexible ligands for complexation with transition metals thus occupying a distinct position in coordination chemistry. 1-(Acyl/aroyl)-3-(substituted)thioureas have also emerged as attractive candidates in various fields such as ion sensors, corrosion inhibitors, molecular electronics, in metal extraction and in pharmaceuticals. The medicinal chemistry of this organo-sulfur framework and the derived metal complexes has witnessed fantastic progress in the current era. In continuation of our efforts to compile data on the structural aspects and numerous applications of 1-(acyl/aroyl)-3-(substituted)thiourea analogs, continuous advances have prompted us to present an overview of the last 2 years literature on this exciting family of compounds through this review article.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

et al. 2016

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“…Synthesis and evaluation of antibacterial activity against S. enterica (SE), M. luteus (ML), B. subtilis (BS) and P. aeruginosa (PS) acylthioureas (38) and diacyl-bis-thioureas (39) have been discussed by Iranian scientists [21]. The authors developed a "one-pot two-step" synthesis of compounds 38 and 39 and their final structure was established by X-ray crystallography (Fig.…”

Section: Resultsmentioning

confidence: 99%

Substituted acyl thioureas and acyl thiosemicarbazides: synthesis and biological activity (minireview)

Kholodniak

Коваленко

2022

SR: PS

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Acyl isothiocyanates and their functional derivatives (acyl thioureas and acyl thiosemicarbazides) are an important group of organic compounds that are widely used in the synthesis of heterocycles and in chemistry as catalysts, ligands, colorimetric hemosensors, etc. In recent years, there has been an increased interest towards this class of compounds as promising biologically active compounds, especially since the latest advances in medicinal chemistry for them are not sufficiently studied. The aim. To summarize and systematize information for the last 10 years on methods of synthesis and biological activity of substituted acyl thioureas and acyl thiosemicarbazides. Materials and methods. Web-tools for finding scientific information (Reaxys, Scopus, Google Scholar, ScienceResearch, SciFinder, Web of Science, etc.). Results and discussion. Literature sources related to the methods of synthesis of substituted acyl thioureas and acyl thiosemicarbazides were systematized and analyzed. The main approaches for the formation of these compounds are revealed: stepwise formation from carboxylic acids, through acyl chlorides and acyl isothiocyanates followed by nucleophilic addition of amines or hydrazides of carboxylic acids ("one-pot synthesis"), nucleophilic addition of amines or hydrazides of carboxylic acids directly to acyl isothiocyanates and parallel microwave synthesis using acyl isothiocyanates and amines as reagents. The possibility of their use as ligands for the formation of complex compounds with transition metal ions was discussed. In the review biological activity of these structures, namely antimicrobial, fungicidal, antitumor, antiviral, antifungal and other activities was detailazed. Conclusions. The basic approaches to the synthesis of substituted acylthuoureas and acyl thiosemicarbazides which include the application of carboxylic acids, their derivatives (acyl halides and isothiocyanates) and N-nucleophiles as initial compounds were discussed. It was shown that aforementioned class of the compounds reveals the versatile biological activity and are promising for further structural modification aimed to the search of novel drugs

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Synthesis, Crystal Structure and Fluorescent Property of Cis-bis[N,N-diethyl-N'-(p-nitrobenzoyl)thiourea-kS,O] Platinum(II) Complex

Duan

Su²,

Liu³

et al. 2022

J Chem Crystallogr

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One-pot and two-step synthesis of novel carbonylthioureas and dicarbonyldithioureas derivatives

Cited by 6 publications

References 14 publications

Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

Substituted acyl thioureas and acyl thiosemicarbazides: synthesis and biological activity (minireview)

Synthesis, Crystal Structure and Fluorescent Property of Cis-bis[N,N-diethyl-N'-(p-nitrobenzoyl)thiourea-kS,O] Platinum(II) Complex

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