2022
DOI: 10.1021/acscatal.2c03052
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One-Pot Biocatalytic Synthesis of Primary, Secondary, and Tertiary Amines with Two Stereocenters from α,β-Unsaturated Ketones Using Alkyl-Ammonium Formate

Abstract: The efficient asymmetric catalytic synthesis of amines containing more than one stereogenic center is a current challenge. Here, we present a biocatalytic cascade that combines ene-reductases (EReds) with imine reductases/reductive aminases (IReds/RedAms) to enable the conversion of α,β-unsaturated ketones into primary, secondary, and tertiary amines containing two stereogenic centers in very high chemical purity (up to >99%), a diastereomeric ratio, and an enantiomeric ratio (up to >99.8:<0.2). Compared with … Show more

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Cited by 14 publications
(11 citation statements)
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“…Moreover, formamides can aid in the increase in the solubility of substrates and are easily removed in further downstream processing. It is vital to note that the system is not yet optimized, giving vast potential for further applications as NAD­(P)­H-dependent synthesis of amines is an important and growing sector for various bioactives …”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, formamides can aid in the increase in the solubility of substrates and are easily removed in further downstream processing. It is vital to note that the system is not yet optimized, giving vast potential for further applications as NAD­(P)­H-dependent synthesis of amines is an important and growing sector for various bioactives …”
Section: Discussionmentioning
confidence: 99%
“…It is vital to note that the system is not yet optimized, giving vast potential for further applications as NAD(P)H-dependent synthesis of amines is an important and growing sector for various bioactives. 6 ■ ASSOCIATED CONTENT * sı Supporting Information…”
Section: ■ Conclusionmentioning
confidence: 99%
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