One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol−Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging

Abstract

Cysteine-modified Fe3O4 nanoparticles (Cys-Fe3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis−condensation of iron(III) allylacetylacetonate and the thiol−ene click reaction. The particle size of Fe3O4 in Cys-Fe3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g−1 at 230 kHz and 100 Oe. In addition, they exhibited a T 2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

Synthesis, structure and magnetic properties of La3Co2SbO9: A double perovskite with competing antiferromagnetic and ferromagnetic interactions

“…6b can be described with a Langevin's function with an extra linear component (M ¼ ½aUcothðbH=TÞÀðbH=TÞ À1 þcH=T) (solid orange curve). The two first terms are due to superparamagnetic behavior which is usually found in magnetic clusters or small particles systems [36]. The last term is a paramagnetic contribution due to isolated and non interacting Co 2 þ .…”

Synthesis and 3D hierarchical organization of 2D structured iron oxide based on enzymatic structure, activity and thermostability

“…The M S of the flowerlike structures was corrected based on the content of organic compounds estimated by TG, giving a corrected M S for the flowerlike structures of 68 emu/g. The ferrimagnetic properties and high surface area of the flower-like structures derived from their unique morphology allows the possibility for their application in environmental and biomedical fields [44][45][46][47][48][49], such as the magnetic separation of rare metals, hazardous elements, DNA or protein, magnetic fluid, magnetic resonance imaging, hyperthermia treatment and 3D magnetic cellular media.…”

Click Chemistry for Drug Delivery Nanosystems

“…One of the main shortcomings in the application of this chemistry to MNP is difficulty synthesizing alkeneimmobilized particles because C-C double bonds undergo polymerization at the high temperature required in this process. This limitation has been recently overcome by Yogo and coworkers by employing allyl groups, which do not undergo polymerization (121). The authors reported modification of allyl-functionalized Fe 3 O 4 NP with cysteine via a one-pot approach hydrolysis-condensation of Fe(III) allylacetylacetonate and TEC (AIBN, EtOH-H 2 O, 60°C).…”