One-pot chemoenzymatic synthesis of glycolic acid from formaldehyde

Li, Tianzhen; Tan, Zijian; Tang, Zijing; Pi, Li; Liu, Haifeng; Zhu, Leilei; Ma, Yanhe

doi:10.1039/d2gc00688j

Cited by 14 publications

(13 citation statements)

References 32 publications

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“…One-carbon compounds are promising feedstocks because of their abundance in nature, nonfood resources, and potential for sustainability . Advances in enzyme engineering allow enzymatic production of valuable compounds and materials from C1 compounds such as CH 4 , CO 2 , CO, formaldehyde, and methanol. − For instance, formate was produced at a high rate from CO gas by a synthetic CO:formate oxidoreductase, designed as an enzyme complex for direct electron transfer between noninteracting CO dehydrogenase and formate dehydrogenase. , …”

Section: Introductionmentioning

confidence: 99%

Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde

Cheon

et al. 2023

ACS Sustainable Chem. Eng.

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A whole-cell biocatalysis was investigated for the selective synthesis of the industrially relevant C2 chemicals (e.g., glycolic acid (3)) from formaldehyde (1). Escherichia coli cells were engineered to overexpress a carboligase and an aldehyde dehydrogenase from E. coli K-12. Moreover, the side reactions, which dissipate formaldehyde and glycolic acid, were removed to produce glycolic acid to a high conversion. Host cell engineering to apply relatively chemical tolerant E. coli strains as well as substrate engineering to avoid the toxic effects of formaldehyde to the host cells allowed production of glycolic acid up to 27 mM in the reaction medium with a conversion of 85%. This study will contribute to valorization of C1 gas (e.g., CH 4 , CO 2 , and CO) to industrially relevant C2 chemicals in a sustainable way.

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Section: Introductionmentioning

confidence: 99%

Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde

Cheon

et al. 2023

ACS Sustainable Chem. Eng.

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“…Poly (glycolic acid) (PGA), 18,19 a synthetic polymer material with high‐level biodegradability, makes it an ideal and versatile material for developing biodegradable and bio‐mass derived plastics to replace nondegradable plastics 20–22 . PGA also exhibits good biocompatibility and can be applied to human tissue and biomedical engineering, such as absorbable surgical sutures, biodegradable cardiovascular stents, and enhancing bone regeneration 23,24 .…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] Worldwide, the development of degradable materials, [13][14][15] has become the "hot spot" to deal with the ecological and environmental problems caused by nondegradable plastics. 16,17 Poly (glycolic acid) (PGA), 18,19 a synthetic polymer material with high-level biodegradability, makes it an ideal and versatile material for developing biodegradable and bio-mass derived plastics to replace nondegradable plastics. [20][21][22] PGA also exhibits good biocompatibility and can be applied to human tissue and biomedical engineering, such as absorbable surgical sutures, biodegradable cardiovascular stents, and enhancing bone regeneration.…”

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confidence: 99%

A hybrid deep learning framework driven by data and reaction mechanism for predicting sustainable glycolic acid production performance

Zhou

Feng

et al. 2023

AIChE Journal

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Selective oxidation at low temperatures without alkali of biomass is a promising and sustainable avenue to manufacture glycolic acid (GA), a biodegradable functional material to protect the environment. However, producing glycolic acid with high selectivity and yield using the traditional research and development approach is timeconsuming and labor-intensive. To this context, a hybrid deep learning framework driven by data and reaction mechanisms for predicting GA production was proposed, considering the lack of related reaction mechanisms in the machine learning algorithms. The proposed hybrid deep learning framework involves the kinetic reaction mechanism, catalyst properties, and reaction conditions. Results showed that the fully connected residual network exhibited superior performance (average R 2 = 0.98) for the prediction of conversion rate and product yields. Then, the multi-objective optimization and experimental verification guided the research are carried out. The experimental verification is comparable to the modeling results, with errors of less than 4% for conversion rate and GA yields. The life cycle assessment further identifies that using the optimized operating parameters, the fossil energy demand and greenhouse emissions have decreased by 2.96% and 3.00%, respectively. This work provides new insight and strategy to accelerate the engineered selective oxidation for desired GA production.

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“…[10] The conventional method for GcA preparation in industry uses chloroacetic acid or formaldehyde as raw material. [11] This method confronts several disadvantages, such as complex reaction routes, harsh condition, dangerous operation, toxic raw materials and environmental pollution. Many efforts have been devoted to exploring sustainable strategies for GcA production.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the demand for glycolic acid as a monomer of polyglycolic acid is sharply growing due to its attractive bio‐degradable property [10] . The conventional method for GcA preparation in industry uses chloroacetic acid or formaldehyde as raw material [11] . This method confronts several disadvantages, such as complex reaction routes, harsh condition, dangerous operation, toxic raw materials and environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

Glycerol Valorization Towards Glycolic Acid Production Over Cu‐Based Biochar Catalyst

et al. 2022

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Glycerol valorization towards high‐value chemicals is of particular importance to increase the value chain of biodiesel production. In this study, the catalytic activity of a series of cheap Cu‐based catalysts for glycerol conversion is investigated. Cu supported on activated carbon (AC, obtained through carbonization of coconut shell) exhibits outstanding catalytic activity for the selective conversion of glycerol into glycolic acid (GcA) in O2 atmosphere, affording up to 68.3 % GcA yield. The combination of experimental results with theoretical calculations reveals that glyceraldehyde is the key reaction intermediate. The high specific surface area and surface oxygenated groups of AC enable the formation of CuO nanoparticles with small size and uniform dispersion. In addition, the surface oxygen vacancy on Cu/AC might help to activate reaction intermediates, and the electron transfer from Cu to AC facilitates the oxidation of glycerol to GcA. Cu loaded onto AC also significantly inhibits C−C breakage to generate formic acid as a byproduct. This work might aid the development of approaches for glycerol application and afford profitable possibilities for sustainable biodiesel.

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One-pot chemoenzymatic synthesis of glycolic acid from formaldehyde

Abstract: Glycolic acid is an important building block of biodegradable polymers. Herein, we report an efficient selective and atom-economic approach for the synthesis of glycolic acid based on a catalytic C-C...

Cited by 14 publications

References 32 publications

Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde

Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde

A hybrid deep learning framework driven by data and reaction mechanism for predicting sustainable glycolic acid production performance

Glycerol Valorization Towards Glycolic Acid Production Over Cu‐Based Biochar Catalyst

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