One-pot conversion of carbamates of unsaturated β-aminoesters into unsaturated β-lactams by use of trimethylsilyl iodide

Abstract

Trimethylsilyl iodide (TMSI) is introduced as an efficient reagent for the one-pot and direct transformation of carbamates of unsaturated β-aminoesters into the corresponding α-methylene-β-lactams and α-arylidene-β-lactams. The mild reaction conditions, excellent yields and easy work-up procedures make it a useful alternative to previously applied procedures for the rapid synthesis of β-lactams from easily available Baylis-Hillman adducts. Downloaded by [University of Sussex Library] at 00:26 01 July 2016 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2

Studies on the Synthesis of Substituted 2-amino-4H-benzo[h]chromene and 3-amino-1H-benzo[f]chromene Derivatives Using Base Supported Ionic Liquid Like-phase (SILLP) as an Efficient Green Catalyst

“…They are the solvents of choice for a large array of organic reactions and can perform as a catalyst at the same time. [16][17][18][19][20][21][22] With respect to our continued interest in developing benign methods for the synthesis of biologically important products, [23][24][25][26][27][28] we report a simple and high-yielding protocol for the synthesis of 2-amino-2-chromenes using SILLP as an efficient and recyclable heterogeneous base catalyst (Scheme 1).…”