One-pot fabricating Fe3O4/graphene nanocomposite with excellent biocompatibility and non-toxicity as a negative MR contrast agent

Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI)

“…SPION also show high biocompatibility, bioactivity, and conformation stability, becoming an interesting alternative to gadolinium-based T 1 contrast agents [15,17,18,19,20,21]. Some studies reported that the aggregation of SPION enhances relaxivity (r 2 ) and increases MRI contrast [22,23,24]. Inside the body, uncontrolled aggregation is not desired, as it causes nanoparticle precipitation, thus reducing their stability, biocompatibility, circulation time and efficiency [22,23,24,25,26,27].…”

“…Some studies reported that the aggregation of SPION enhances relaxivity (r 2 ) and increases MRI contrast [22,23,24]. Inside the body, uncontrolled aggregation is not desired, as it causes nanoparticle precipitation, thus reducing their stability, biocompatibility, circulation time and efficiency [22,23,24,25,26,27].…”

“…To overcome these limitations, SPION have been combined with different stable supports, such as carbon materials, in order to prevent the agglomeration in the organism, enable a good dispersion and improve their circulation time and efficiency [19,22,23,24,28]. The combination also takes advantage of the intrinsic properties of both materials [27], and an MRI contrast enhancement has also been observed by the interaction of magnetic nanoparticles loaded onto neighbouring nanocarriers [29].…”

“…Different methods have been proposed in order to obtain decoration of GO or RGO in situ with iron oxide nanoparticles, such as co-precipitation [44,45], hydrothermal [23], or solvothermal approaches [42,46,47]. Some other strategies have been based on the decoration of graphene compounds by an ex situ approach: synthetizing first the nanoparticles and then attaching them onto the graphene surface [14].…”

PES magnetic microspheres: preparation and performance for the removal of endocrine disruptor-BPA

“…In this way they can be separated directly from the environment. Magnetic microspheres have attracted much attention in recent years and will be potentially used in many elds, such as wastewater treatment, 19,20 enzyme immobilization, 21 magnetic resonance imaging (MRI) 22 and cell separation, 23 etc. Conventionally, the preparation methods include monomer polymerization 24,25 and embedding method, 26,27 both involving the synthesis of magnetic particles as well as the microspheres and the following binding of particles and microspheres.…”