One-pot fabrication of polymer micro/nano-discs via phase separation and a roll-to-roll coating process

Tuntanatewin, Waranyou; Tani, Kazuki; Ishikura, Kenichi; Zhang, Hong; Okamura, Yosuke

doi:10.1016/j.colsurfa.2019.124274

Cited by 9 publications

(10 citation statements)

References 47 publications

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“…Our previous study of one‐pot fabrication via phase separation and roll‐to‐roll coating process were utilized to fabricate PLGA domains on PVA film 35 . As shown in Figure 2(a) of no stretching, frozen structure of island‐like phase‐separated PLGA domains from a PLGA/PVP blend on PVA film were apparently observed at total concentration of 4 wt% with blend ratio of 1:4 (wt/wt).…”

Section: Resultsmentioning

confidence: 99%

“…By this method, discs can be collected in a one-pot by repeated cycles of centrifugation and washing with water, which is considered to be more an environmentally friendly approach. 35 PVA film, which was used as a coating substrate in our previous study, has excellent extendibility with a good heat resistance. Therefore, there is high potential to combine roll-to-roll machine via polymer phase separation method with film stretching for fabrication of polymer particles with further peculiar shapes.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study, we have proposed a method to fabricate discs in a continuous manner using the roll‐to‐roll machine via polymer phase separation. By this method, discs can be collected in a one‐pot by repeated cycles of centrifugation and washing with water, which is considered to be more an environmentally friendly approach 35 . PVA film, which was used as a coating substrate in our previous study, has excellent extendibility with a good heat resistance.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness

Tuntanatewin

Mekwatanakarn

Zhang

et al. 2020

J of Applied Polymer Sci

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The key factor of polymer particles using as a drug carrier is the ability to adhere to the surface of the target sites in order to optimize the drug delivery efficiency. To this end, shape of the particles is one of the essential parameters since nonspherical particles such as discs theoretically have more contact surface area than spherical particles. We herein propose a facile method to fabricate elongated polymer micro/nano discs by combining phase separation and a roll-to-roll coating process with a stretching method. By roll-to-roll coating, biodegradable poly(lactide-co-glycolide) (PLGA) discs formed on polyvinyl alcohol (PVA) film can be instantly stretched by uniaxial stretcher. The effect of stretching temperature and percentage of film elongation on the particle morphology was studied. The results showed that the PLGA discs can be elongated and the aspect ratio of 2.3 can be achieved with 600% elongation at 80 C, reflecting the increase of estimated contact surface area by 1.8 times. The adhesion efficiency of these elongated discs was compared with discs before stretching, spheres, and elongated spheres by using the water-dropping test. The elongated discs showed the best result among these particles and their adhesion efficiency are strongly related to estimated contact surface area.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness

Tuntanatewin

Mekwatanakarn

Zhang

et al. 2020

J of Applied Polymer Sci

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“…Particles with shape anisotropy have homogeneous composition throughout the particle with anisotropy in shape, whereas compositional anisotropy arises from heterogeneous composition in a single particle, e.g., multicompartmental or Janus particles. In past few years, a wide variety of anisotropically shaped biocompatible polymeric particles have been introduced such as ellipsoid, needle shaped, disks, cubic shape, rod shape, cylinders, cups, trojan, toroidal spiral, etc., where particle shape has been shown to have profound influence on cellular uptake, targeted drug delivery, targeted gene delivery, optical properties, enhanced binding, targeted cellular internalization etc., thus inspiring the researchers to further develop novel strategies to synthesize anisotropic particles. On the other side, Janus or multicompartmental particles are a kind of particle system that exhibits a good control over multifunctional properties (chemical or physical or both) spaced in different compartments, e.g., it provides a facile route to directly incorporate two or more drugs/therapeutic agents in a single particle with independent release rates depending on the matrix of individual compartments, opening a new paradigm for drug-delivery applications .…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Anisotropic Polymeric Particles: Synthesis, Characterization, and Biomedical Applications

Mirza

Saha

2020

ACS Appl. Bio Mater.

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Recently, biocompatible anisotropic particles have emerged as a powerful platform in the biomedical field, especially in the areas such as therapeutics, theranostics, biosensor, targeted drug delivery, triggered drug delivery, cellular uptake, targeted cellular internalization, etc., because of their unique characteristics and superior performances over their isotropic analogues. Macromolecular anisotropic particles can primarily be classified into three different categories, such as shape anisotropy, compositional anisotropy, and surface anisotropy, i.e., heterogeneous surface chemistry leading to anisotropic surface patches. In this review, we have attempted to give an overview on the biocompatible anisotropic polymeric particles related to their synthesis and applications in biomedical arena with emphasis on their fascinating properties over spherical particles. A brief summary of their future developments is also highlighted.

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“…They can be broadly classified into two categories, bottom-up and top-down. The former one includes but is not limited to the following methods: seeded dispersion polymerization, electrospray, disassembling of stacked block copolymer particles, cosurfactant crystallization-assisted emulsion droplets, and removing matrix domains in phase-separated thin films. , In the latter category, the polymer is thermal or mechanical deformed, or template-assisted processed, such as stretching of spherical particles in the film, , particle replication in nonwetting templates (PRINTs), direct lithography, thermal fusion of particles, , blown film process, stirring of particle suspensions, fragmentation of thin films, and template-based wetting . The current methods, however, are still somewhat limited by high cost, low yield, process complexity, or shape polydispersity.…”

Section: Introductionmentioning

confidence: 99%

Polymer Discs with High Interfacial Adhesion Fabricated from Hot-Pressing of Microspheres

Zhang

Tuntanatewin

Ishikura

et al. 2020

ACS Appl. Polym. Mater.

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Owing to the large contact surface area in geometry, disc-shaped polymer particles and their fascinating properties compared to those of spherical particles have received increasing attention. Although a variety of methods have been developed, fabricating polymer discs in a facile and versatile manner remains a challenge. In this study, we propose a method to fabricate polymer discs by a hot-press process combined with a sacrificial matrix technique, where only aqueous solutions and suspensions are employed. By embedding polymer microspheres in alginate gel, space between the microspheres is created, and thus, the microspheres can be deformed into individual discs after hotpressing near the T g of the polymer. As case studies, polystyrene, poly(L-lactic acid), and poly(D,L-lactide-co-glycolide) microspheres with a wide range of sizes were processed into polymer discs. The choice of sacrificial matrix and the optimal condition for hot-pressing are also discussed. Moreover, the high interfacial adhesion of the prepared discs was verified, including the adhesiveness of polymer discs to the surface of a cover glass under airflow, as well as the enhancement of aggregation for bovine serum albumin-coated polymer discs in the presence of glutaraldehyde. We suggest that the enhanced adhesiveness of polymer discs can improve their performances in both particle-based targeted drug delivery and latex turbidimetric immunoassay.

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One-pot fabrication of polymer micro/nano-discs via phase separation and a roll-to-roll coating process

Cited by 9 publications

References 47 publications

Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness

Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness

Biocompatible Anisotropic Polymeric Particles: Synthesis, Characterization, and Biomedical Applications

Polymer Discs with High Interfacial Adhesion Fabricated from Hot-Pressing of Microspheres

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