One-pot fabrication of uniform half-moon-shaped biodegradable microparticles via microfluidic approach

Im, Jinsol; Jang, Eun Kwang; Yim, DaBin; Kim, Jong-Ho; Cho, Kuk Young

doi:10.1016/j.jiec.2020.07.007

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…These microplastics flow out to the ocean and accumulate in the sea for a long time without any significant biodegradation. Therefore, primary small plastics must immediately be substituted with biodegradable alternatives, with many studies on enhancing the biodegradability of synthetic polymers having been conducted to develop environmentally friendly polymer microparticles [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Preparation and Characterization of Spherical Microparticles Composed of Artificial Lignin and TEMPO-Oxidized Cellulose Nanofiber

2021

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A one-pot and one-step enzymatic synthesis of submicron-order spherical microparticles composed of dehydrogenative polymers (DHPs) of coniferyl alcohol as a typical lignin precursor and TEMPO-oxidized cellulose nanofibers (TOCNFs) was investigated. Horseradish peroxidase enzymatically catalyzed the radical coupling of coniferyl alcohol in an aqueous suspension of TOCNFs, resulting in the formation of spherical microparticles with a diameter and sphericity index of approximately 0.8 μm and 0.95, respectively. The ζ-potential of TOCNF-functionalized DHP microspheres was about −40 mV, indicating that the colloidal systems had good stability. Nanofibrous components were clearly observed on the microparticle surface by scanning electron microscopy, while some TOCNFs were confirmed to be inside the microparticles by confocal laser scanning microscopy with Calcofluor white staining. As both cellulose and lignin are natural polymers known to biodegrade, even in the sea, these woody TOCNF−DHP microparticle nanocomposites were expected to be promising alternatives to fossil resource-derived microbeads in cosmetic applications.

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Section: Introductionmentioning

confidence: 99%

Enzymatic Preparation and Characterization of Spherical Microparticles Composed of Artificial Lignin and TEMPO-Oxidized Cellulose Nanofiber

2021

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Recent Advances in Microfluidic Technologies for the Construction of Artificial Cells

Tan

Yin

et al. 2023

Adv Funct Materials

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Artificial cells are synthetic constructs that emulate natural cells, with potential applications in areas of energy science, environmental treatment, and the study of life's origins. Nevertheless, the construction of artificial cells is a formidable undertaking, given the intricate nature of natural cells in structures, functions, and working mechanisms. With precise control, high automation, and excellent uniformity, microfluidics has emerged as a promising approach for the construction of artificial cells. This review summarizes the latest microfluidic techniques utilized to construct artificial cells, ranging from simple droplets to sophisticated cell‐inspired systems. These include the generation of droplets, the production of vesicles (lipid‐based and polymer‐based vesicles), the fabrication of polymeric microparticles with various compartments, shapes, and microstructures, as well as the manufacture of sophisticated cell‐inspired systems. The characteristics of different methods for the construction of artificial cells are discussed in detail. Furthermore, the wide‐ranging applications of artificial cells are also showcased. Finally, contemporary obstacles and forthcoming advancements are discussed in the field of microfluidic‐based artificial cells. This review is supposed to stimulate research in the construction of more functional and natural‐like artificial cells, as well as works in the fields of material, biology, environment, medicine, and energy.

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Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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Natural materials are anisotropic. Delivery systems occurring in nature, such as viruses, blood cells, pollen, and many others, do have anisotropy, while delivery systems made artificially are mostly isotropic. There is apparent complexity in engineering anisotropic particles or capsules with micron and submicron sizes. Nevertheless, some promising examples of how to fabricate particles with anisotropic shapes or having anisotropic chemical and/or physical properties have been developed. Anisotropy of particles, once they face biological systems, influences their behaviour. Internalisation by the cells, flow in the bloodstream, biodistribution over organs and tissues, directed release, and toxicity of particles regardless of the same chemistry are all reported to be factors of anisotropy of delivery systems. Here, we review the current methods to introduce anisotropy to particles or capsules, including loading with various therapeutic cargo, variable physical properties primarily by anisotropic magnetic properties, controlling directional motion, and making Janus particles. The advantages of combining different anisotropy in one entity for delivery and common problems and limitations for fabrication are under discussion.This article is protected by copyright. All rights reserved

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One-pot fabrication of uniform half-moon-shaped biodegradable microparticles via microfluidic approach

Cited by 7 publications

References 25 publications

Enzymatic Preparation and Characterization of Spherical Microparticles Composed of Artificial Lignin and TEMPO-Oxidized Cellulose Nanofiber

Enzymatic Preparation and Characterization of Spherical Microparticles Composed of Artificial Lignin and TEMPO-Oxidized Cellulose Nanofiber

Recent Advances in Microfluidic Technologies for the Construction of Artificial Cells

Features of Anisotropic Drug Delivery Systems

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