One-pot four-component synthesis of novel isothiourea-ethylene-tethered-piperazine derivatives

Hajizadeh, Fatima; Mojtahedi, Mohammad M.; Abaee, M. Saeed

doi:10.1039/d3ra06678a

RSC Adv.

2023

DOI: 10.1039/d3ra06678a

|View full text |Cite

One-pot four-component synthesis of novel isothiourea-ethylene-tethered-piperazine derivatives

Fatima Hajizadeh,

Mohammad M. Mojtahedi,

M. Saeed Abaee

Abstract: A multicomponent synthesis of piperazines tethered to isothiourea group via an ethylene link was developed. Several derivatives of the target products are formed by combination of DABCO, alkyl bromides, secondary amines, and phenylisothiocyanate.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Chain Extension of Piperazine in Ethanol: Synthesis of 2-(4-(2-(Phenylthio)ethyl)piperazinyl)acetonitriles and ACAT-1 Inhibitors

Huang,

Zhu,

et al. 2024

Molecules

View full text Add to dashboard Cite

A base-induced synthesis of 2-(4-(2-(phenylthio)ethyl)piperazinyl) acetonitriles by reaction of disulfides, 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride and trimethylsilyl cyanide is reported. The scope of the method is demonstrated with 30 examples. The reaction mechanism research indicates that the three-component reaction would be a SN2 reaction. The products exhibit good activities towards advanced synthesis of aqueous soluble acyl-CoA: cholesterol O-acyltransferase-1 (ACAT-1) inhibitors. Our work is superior as it uses less-odor disulfides as carbon sources and EtOH as solvent in a water and dioxygen insensitive reaction system, followed by a simple purification process.

show abstract

Chain Extension of Piperazine in Ethanol: Synthesis of 2-(4-(2-(Phenylthio)ethyl)piperazinyl)acetonitriles and ACAT-1 Inhibitors

Huang,

Zhu,

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

One-pot four-component synthesis of novel isothiourea-ethylene-tethered-piperazine derivatives

Abstract: A multicomponent synthesis of piperazines tethered to isothiourea group via an ethylene link was developed. Several derivatives of the target products are formed by combination of DABCO, alkyl bromides, secondary amines, and phenylisothiocyanate.

Cited by 1 publication

References 36 publications

Chain Extension of Piperazine in Ethanol: Synthesis of 2-(4-(2-(Phenylthio)ethyl)piperazinyl)acetonitriles and ACAT-1 Inhibitors

Chain Extension of Piperazine in Ethanol: Synthesis of 2-(4-(2-(Phenylthio)ethyl)piperazinyl)acetonitriles and ACAT-1 Inhibitors

Contact Info

Product

Resources

About