One‐pot, Gram‐Scale Synthesis of Calix[5]‐ and Calix[6]furan: Derivatization for Polyketone‐ and Isopyrazole‐based Macrocycles with Conformational Analysis
Tomoki Yoneda,
Taichi Sano,
Narendra Nath Pati
et al.
Abstract:A gram‐scale synthesis of calix[5]‐ and calix[6]furan was achieved by a one‐pot condensation of furan and acetone followed by stepwise separation of calix[n]furans (n = 4–6) using size‐selective precipitation procedures. Calix[n]furans were converted to cyclic polyketones and then to ethylene‐bridged cyclic isopyrazoles. The conformational analysis of the cyclic furan, polyketone, and isopyrazole macrocycles was performed based on their single crystal structures, providing important structural insights for int… Show more
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