One-pot green synthesis of isoxazol-5(4H)-one derivatives by Dowex1-x8OH in water

Abstract

4-(Аrylmethylidene)-3-methylisoxazol-5(4H)-ones and 4-(arylmethylidene)-3-phenylisoxazol-5(4H)-ones were synthesized in a one-pot three-component procedure in the presence of Dowex1-x8OH as catalyst in water. The products were obtained in high yields (90-95 %) and proper reaction times (1-5 h). The method is eco-friendly and operationally simple.

Synthesis and characterization of Fe3O4/PEG-400/oxalic acid magnetic nanoparticles as a heterogeneous catalyst for the synthesis of pyrrolin-2-ones derivatives

“…Also, for extension of green chemistry, we have reported several eco-friendly procedures for the synthesis of heterocyclic compounds. 11,31 On the other hands, for a synthetic project we had needed a series of pyrrolin-2ones. Encouraged by these results, we turned our attention to new methodology for the synthesis of 3-acyl-5-hydroxy-3-pyrrolin-2-one derivatives from aldehydes, anilines and dimethyl acetylenedicarboxylate (DMAD) catalyzed by Fe3O4/PEG-400/oxalic acid as a novel reusable magnetic nano-catalyst under room temperature as shown in Scheme 1.…”

Novel donor-acceptor systems bearing an isoxazol-5-one core

“…Namely, the multicomponent reactions between ethyl acetoacetate, hydroxylamine and aromatic aldehydes afford the corresponding isoxazol-5-ones in the presence of acid or base, in high yields. [15][16][17] It is noteworthy that methods leading to products bearing an ester group at position 3 are essentially unknown even though the role of this synthetic handle cannot be underestimated. Thus, there is still a strong need for a new synthetic tool in the preparation of isoxazol-5ones, allowing for their convenient post-functionalization.…”

Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free conditions

“…In recent years, organic chemists have focused their attention towards green chemistry for the synthesis of heterocyclic compounds using multi-component domino reactions (MCRs) [1][2][3][4][5][6] due to a broad range of notable advantages, such as non-toxic substrate and environmental friendliness. Atom economy, reduction in by-products, number of steps in an organic synthesis, energy cost, produced waste, use of non-hazardous reagents in catalytic protocols are some of the most important goals of green chemistry.…”