One-pot Lewis acid assisted synthesis of indole-3-sulfonamide and imidazo[1,2-a]pyridine-3-sulfonamide using Burgess reagent in a microwave reactor

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

“…[1][2][3][4] These compounds have demonstrated significant applications in pharmaceuticals, agrochemicals, food processing, and other industries. [5][6][7] Specifically, imidazo [1,2-a]pyridine derivatives, a subclass of imidazopyridines, are of particular interest due to their promising therapeutic potential in various medical fields. [8][9][10] They exhibit diverse pharmacological activities, including anticancer, anti-inflammatory, antiulcer, analgesic, antiprotozoal, antipyretic, antiviral, and other activities.…”

“…Heterocyclic compounds, particularly those with nitrogen atoms in their structure, such as imidazopyridines, have garnered significant attention in various fields due to their versatile properties and diverse biological activities [1–4] . These compounds have demonstrated significant applications in pharmaceuticals, agrochemicals, food processing, and other industries [5–7] . Specifically, imidazo[1,2‐a]pyridine derivatives, a subclass of imidazopyridines, are of particular interest due to their promising therapeutic potential in various medical fields [8–10] .…”

Metal-free introduction of primary sulfonamide into electron-rich aromatics

“…[39][40][41] Recently it has also been used for preparing sulfonamide, but functional group tolerance was limited since an organometallic reagent or Lewis acid/heating was needed for activation. [42][43][44] In fact, N-sulfonylamine (or azasulfene) was proposed in Burgess's early report as an elusive intermediate for the preparation of the Burgess reagent, and trapping it with nucleophiles such as amine or alkene to form sulfamide or a cycloadduct was successfully demonstrated. 45,46 However, N-sulfonylamine was only detected and characterized by matrix-isolation IR spectroscopy in 2016, largely due to its high instability.…”