One-pot mediated synthesis of pyrimidine and quinazoline annulated derivatives of nitrogen containing five membered rings through their nitrile derivatives as antibacterial agents

A. Gosalia, Umang; Srivastava, Manish; Yaduvanshi, Neetu; Jaiswal, Shivangi; Jain, Sonika; Kishore, Dharma; Dwivedi, Jaya; Sharma, Swapnil

doi:10.4314/bcse.v37i5.12

Bull. Chem. Soc. Eth.

2023

DOI: 10.4314/bcse.v37i5.12

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One-pot mediated synthesis of pyrimidine and quinazoline annulated derivatives of nitrogen containing five membered rings through their nitrile derivatives as antibacterial agents

Umang A. Gosalia,

Manish Srivastava,

Neetu Yaduvanshi

et al.

Abstract: ABSTRACT. Novel five-membered ring (pyrrole, pyrazole and imidazole)-based pyrimidine and quinazoline derivatives were synthesized by one-pot domino approach. This approach has the advantages of high yield, mild reaction conditions and a simple work-up procedure. The structure of the synthesized compound was elucidated by spectroscopy technique and elemental analysis. The synthesized compound were examined for antimicrobial activity against four bacteria (E. coli, S. pyogenes, S. aureus, and P. aeruginosa) and… Show more

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2024

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Cited by 2 publications

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Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

Jaiswal,

Dwivedi,

Kishore

et al. 2024

COC

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Tetrazole is a most versatile pharmacophore of which more than twenty FDA-approved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review focuses on the green synthetic approach for the preparation of tetrazole derivatives from different starting materials such as nitrile, isonitrile, carbonyl, amine, amide, oxime and terminal alkyne functions. The mechanism of tetrazole synthesis from different substrates is discussed. In addition to this, a four component Ugi-azide reaction to the tetrazole synthesis is also described. Of note, the present articles exploited several water-mediated and solventfree methodologies for tetrazole synthesis. The important key features of tetrazole synthesis were pinpointing in each synthetic scheme which provides excellent guide to those searching for selective procedure to achieve the desired transformation. This review seeks to present a timely account (2011-2023) on the splendid array of ecofriendly procedures of synthesis known today for the preparation of tetrazole derivatives from different starting materials. The rational of this review is to enlighten recent advancements in the synthesis of tetrazole derivatives from different substrates.

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Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

Jaiswal,

Dwivedi,

Kishore

et al. 2024

COC

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One-pot Synthesis of Condensed Azepines

Bhardwaj,

Jaiswal,

Bhardwaj

et al. 2024

COC

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Azepine is a privileged nitrogen-containing ring that has been found to display a wide range of biological activities. Azepine is a valuable skeleton in designing novel compounds in medicinal chemistry due to its interesting chemical and biological properties. The study on the synthesis of this ring system engenders a fascinating area of research owing to its potential to form an active pharmacophore for De Novo exploration. In this study, conventional and domino results were compared to access the diverse set of azepines in high yield. The domino approach has revolutionized the way through which the previously impossible yet significant transformations could be conceptualized, allowing the construction of difficult materials in one step. The aim of the present mini-review is to highlight the importance of the one-pot domino reaction for the synthesis of condensed azepines. This review also presents research on this subject from the past two decades.

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One-pot mediated synthesis of pyrimidine and quinazoline annulated derivatives of nitrogen containing five membered rings through their nitrile derivatives as antibacterial agents

Cited by 2 publications

References 36 publications

Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

One-pot Synthesis of Condensed Azepines

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