One-pot multi-component synthesis of polyhydroquinolines at ambient temperature

Bismuth(III) bromide catalyzed synthesis of polyhydroquinoline derivatives via the Hantzsch reaction

“…21 Their syntheses have also been reported under catalyst-free conditions, but the methods suffer from longer reaction times. 22 Solvent and catalyst-free methods involving grinding the reaction mixtures have also been reported and are certainly attractive from a green chemistry perspective. But these methods require the use of solvent for product isolation and are not always amenable to scale-up.…”

Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions

“…When the β -ketoester is replaced by an 1,3-dicarbonyl cyclic compound in the Hantsch MCR more structurally complex 1,4-DHPs are formed, such as the polyhydroquinolines (PHQs) ( 5 and 7 ) [122] . The PHQs have received much attention in recent years, due to reports of various therapeutic properties associated with them, including antimalarial [123] and antidiabetic [124] .…”

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

“…[44][45][46] Considering these valuable medicinal applications, we decided to study the catalytic activity of Fe 3 O 4 MNPs-OSO 3 H for the synthesis of Polyhydroquinolines. Initially, to find out optimum reaction conditions and understand the effect of various parameters (such as solvent type, catalyst loading and temperature) on four-component reactions, the reaction of 4-chlorobenzaldehyde (5a), ethyl acetoacetate, dimedone and ammonium acetate was chosen as model reaction.…”