One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst

A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

“…Moreover, it is also expecting from chemists to synthesize compounds by the green and environment friendly approaches. and therefore many researchers have tried to overcome these disadvantages, [18][19][20][21] but these researchers are not in a position to solve the problems like long reaction time, [22] expensive catalysts [23][24][25] or very acidic conditions. [17] Since then it is widely used to synthesize pyrimidinthiones.…”

“…Yet this reaction has some disadvantages like low yields, long reaction time, harsh reaction conditions, and so forth. and therefore many researchers have tried to overcome these disadvantages, [18][19][20][21] but these researchers are not in a position to solve the problems like long reaction time, [22] expensive catalysts [23][24][25] or very acidic conditions. [26] In continuation to this, in the present work, we have reported a simple and efficient methodology for the synthesis of dihydropyrimidinthiones via the condensation of aldehyde, substituted acetophenones and thiourea.…”