One-pot multicomponent synthesis of highly functionalized bio-active pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives using ZrO₂ nanoparticles as a reusable catalyst

Abstract

Herein, a facile one-pot multicomponent protocol for the synthesis of biologically important pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been demonstrated using ZrO2 nanoparticles as reusable catalyst at room temperature.

Multifunctional zirconium oxide doped chitosan based hybrid nanocomposites as bone tissue engineering materials

“…Nano-ZrO2 was synthesized as per the previously reported method (Saha, Payra, & Banerjee, 2015). Briefly, sodium hydroxide (HiMedia Private Ltd.) solution (40 ml 0.05M) in distilled water was slowly added in zirconium oxychloride octahydrate (ZrO2Cl2.8H2O, Merck India Ltd.) solution (100 ml 0.01M) in methanol-water (1:1) at low temperature (5 o C) with continuous stirring for 1 hour.…”

On Water Cu@g‐C3N4 Catalyzed Synthesis of NH‐1,2,3‐Triazoles via [2+3] Cycloadditions of Nitroolefins/Alkynes and Sodium Azide

“…[73] However, to the best of our knowledge, g-C 3 N 4 supported copper chloride (Cu@g-C 3 N 4 ) material has not been reported in the literature. As a part of continuous interest in the development of heterogeneous synthetic methodologies using nanomaterials, [88][89][90][91][92][93] here, we have developed Cu@g-C 3 N 4 for the [3 + 2]cycloaddition of nitroolefins/alkynes with sodium azide leading to NH-1,2,3triazoles (Scheme 1).…”

Ultrasound mediated green synthesis of pyrano[2,3-c]pyrazoles by using Mn doped ZrO2

“…Pyrazole derivatives have occupied a vital place in drug research because of their various biological and pharmacological activities such as antibacterial (Tanitame et al, 2004), antifungal (Ragavan et al, 2010), antioxidant (Daiane et al, 2014), anticancer , antileishmanial (Faria et al, 2013), hypotensive (Arya et al, 1969), antiallergenic (Parsia et al, 1981) activities etc. Subsequently, several reports for the synthesis of these compounds have been reported including the use of TEA (Litvinov et al, 2009), Per-6-ABCD (Kuppusamy and Kasi, 2010), (Javad et al, 2012), TEABr (Kumar et al, 2007), [Dsim]AlCl 4 (Ahmad et al, 2013), FeNi 3 /SiO 2 /HPGMNP (Mohammad and Seyed, 2013), NaOH/microwave (Kathrotiya and Patel, 2012), Δ/reflux (Zonouz et al, 2012), Δ/CH 3 COOH (Gein et al, 2014), UV (Zou et al, 2011), Microwave (Sharma et al, 2016), Meglumine (Guo et al, 2013), Sproline (Khoobi et al, 2015), ZrO 2 (Saha et al, 2015), Fe 3 O 4 @SiO 2 (Soleimani et al, 2015), 1- (Bodhak et al, 2015) and SnO 2 (Paul et al, 2014). Several of these methods face few or more limitations such as, using expensive reagents and catalysts, strong acidic or basic conditions, toxic reagents, tedious steps, strict reaction conditions, low product yields and long reaction times, which limit their use in practical applications.…”