One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines

Abstract

In this work, we synthesized a novel arylidene malononitrile 3 via the treatment of o-alkyl vanillin derivative 1 with malononitrile 2 in the presence of triethylamine (TEA) as a catalyst. The arylidene malononitrile 3 was subjected to react under one-pot multicomponent reaction (MCR) condition with respective methylarylketones 4a-f and sodium ethoxide 5 in ethanol to afford a new series of 2-(4-(6-aryl-3-cyano-2-ethoxypyridin-4-yl)-2-methoxyphenoxy)-N-phenylacetamides 6a-f. The structure of the new products was assured via spectral and elemental analysis. The reaction mechanism was suggested.