One‐Pot, Open‐Air Synthesis of Flexible and Degradable Multifunctional Polymer Composites with Adhesion, Water Resistance, Self‐Healing, Facile Drug Loading, and Sustained Release Properties

Abstract

Developing proper wound management via wound dressings represents a global challenge. Ideal wound dressings shall encompass multiple integrated functionalities for variable, complex scenarios; however, this is challenging due to the complex molecular design and synthesis process. Herein, polymer composites, cross‐linked poly(styrene oxide‐co‐hexaphenylcyclotrisiloxane)/crosslinked poly(hexaphenylcyclotrisiloxane) (cP(SO‐co‐HPCTS)/cPHPCTS) with multiple functionalities are prepared by a one‐step, open‐air method using catalytic ring‐opening polymerization. The introduction of a mobile polymer cP(SO‐co‐HPCTS) endows the composite with good flexibility and self‐healing properties at human body temperature. The hydrophobic groups in the main chain provide hydrophobicity and good water resistance, while the hydroxyl groups contained in the end groups enable good adhesion properties. Drugs can be efficiently loaded by blending and then sustainably release from the polymer composite. The material can rapidly degrade in a tetrahydrofuran solution of tetrabutylammonium fluoride due to its SiOSi bonds. The facile, one‐step, open‐air synthesis procedure and multiple functional properties integrated into the composites provide good prospects for their extensive application and batch production as wound dressing materials.