One-pot photoenzymatic synthesis of maleic acid and its derivatives from bio-based furfural <i>via</i> catalytic cascades

Biomass assumes an increasingly vital role in the realm of renewable energy and sustainable development due to its abundant availability, renewability, and minimal environmental impact. Within this context, 5‐hydroxymethylfurfural (HMF), derived from sugar dehydration, stands out as a critical bio‐derived product. It serves as a pivotal multifunctional platform compound, integral in synthesizing various vital chemicals, including furan‐based polymers, fine chemicals, and biofuels. The high reactivity of HMF, attributed to its highly active aldehyde, hydroxyl, and furan ring, underscores the challenge of selectively regulating its conversion to obtain the desired products. This review highlights the research progress on efficient catalytic systems for HMF synthesis, oxidation, reduction, and etherification. Additionally, it outlines the techno‐economic analysis (TEA) and prospective research directions for the production of furan‐based chemicals. Despite significant progress in catalysis research, and certain process routes demonstrating substantial economics, with key indicators surpassing petroleum‐based products, a gap persists between fundamental research and large‐scale industrialization. This is due to the lack of comprehensive engineering research on bio‐based chemicals, making the commercialization process a distant goal. These findings provide valuable insights for further development of this field.This article is protected by copyright. All rights reserved

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Expanding the Synthetic Toolbox: Discovery of a Robust Aldehyde Dehydrogenase for Integrated Chemocatalysis and Enzyme Catalysis

Sha,

Yu,

Dai

et al. 2024

Adv Synth Catal

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Chemobiocatalysis has recently emerged as a promising tool in organic synthesis; nonetheless, chemobiocatalytic transformations remain challenging due to the incompatibility between the two types of catalysts. Many enzymes, especially aldehyde dehydrogenases (ALDHs), are readily inactivated under the chemocatalytic conditions. Herein, we present a robust NADP+‐dependent p‐hydroxybenzaldehyde dehydrogenase from Pseudomonas aeruginosa (PaHBDH) for integrated chemo‐ and enzyme catalysis. Apart from good activities toward a number of aromatic aldehydes, PaHBDH showed excellent thermal and storage stability in the absence of any stabilizer, but was also highly tolerant toward various organic solvents. The usefulness of PaHBDH in integrated catalysis was demonstrated by the synthesis of a group of aromatic carboxylic acids in good yields by combining with photo‐/electrochemical NADP+ regeneration. The photoenzymatic approach was further extended by integrating with a chemo(bio)catalytic cascade in one pot to allow for the conversion of furfural into value‐added C4 chemicals. The finding of this work may expand the synthetic toolbox for integrated catalysis.

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One-pot photoenzymatic synthesis of maleic acid and its derivatives from bio-based furfural via catalytic cascades

Abstract: Recently, catalytic valorization of biomass-driven furfural has attracted great interest. In this work, we report a one-pot photoenzymatic route toward maleic acid (MA) and its C4 derivatives fumaric acid (FA)...

Cited by 10 publications

References 58 publications

Greener preparation of a flexible material based on macaw palm oil derivatives and CO₂

Greener preparation of a flexible material based on macaw palm oil derivatives and CO₂

5‐Hydroxymethylfurfural and its Downstream Chemicals: A Review of Catalytic Routes

Expanding the Synthetic Toolbox: Discovery of a Robust Aldehyde Dehydrogenase for Integrated Chemocatalysis and Enzyme Catalysis

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One-pot photoenzymatic synthesis of maleic acid and its derivatives from bio-based furfural via catalytic cascades

Abstract: Recently, catalytic valorization of biomass-driven furfural has attracted great interest. In this work, we report a one-pot photoenzymatic route toward maleic acid (MA) and its C4 derivatives fumaric acid (FA)...

Cited by 10 publications

References 58 publications

Greener preparation of a flexible material based on macaw palm oil derivatives and CO2

Greener preparation of a flexible material based on macaw palm oil derivatives and CO2

5‐Hydroxymethylfurfural and its Downstream Chemicals: A Review of Catalytic Routes

Expanding the Synthetic Toolbox: Discovery of a Robust Aldehyde Dehydrogenase for Integrated Chemocatalysis and Enzyme Catalysis

Contact Info

Product

Resources

About

Greener preparation of a flexible material based on macaw palm oil derivatives and CO₂

Greener preparation of a flexible material based on macaw palm oil derivatives and CO₂