One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication

Abstract

Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.

Antibacterial Bionanocomposites Based on Drug-Templated Bifunctional Mesoporous Silica Nanocontainers

“…These shortcomings have led to the emergence and fairly rapid development of an alternative approach [ 5 , 8 , 9 , 13 , 14 , 15 , 16 ]. It is based on the use of an amphiphilic functional compound (e.g., a drug or corrosion inhibitor) as a templating agent.…”

“…It is based on the use of an amphiphilic functional compound (e.g., a drug or corrosion inhibitor) as a templating agent. It allows one to combine the stages of particle synthesis and to load not only one but several target compounds [ 5 , 8 , 9 , 14 , 15 , 16 ]. This possibility exists due to the ability of hydrophobic compounds to be solubilized in surfactant micelles.…”

“…Moreover, they are sensitive to medium pH. It allows one to finely control the release rate of the encapsulated substance without any additional modifications to the MSNs’ surface [ 5 , 8 , 9 , 13 , 14 , 15 , 16 ]. In particular, it has been shown [ 8 , 9 ] that the introduction of such MSNs into paint coatings provides long-term corrosion protection of metal alloys due to the prolonged release of encapsulated compounds.…”