One-pot preparation of pH- and redox-responsive polymeric microgel as an efficient carrier for improved breast cancer therapy

Huang, Di; Zhu, Jing; Xu, Meng-Fan; Chen, Jie; Gao, Xing; Zhao, Long; Ding, Feng; Wu, Cheng-Zhu

doi:10.1016/j.colsurfa.2024.133320

Colloids and Surfaces A: Physicochemical and Engineering Aspect

2024

DOI: 10.1016/j.colsurfa.2024.133320

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One-pot preparation of pH- and redox-responsive polymeric microgel as an efficient carrier for improved breast cancer therapy

Di Huang,

Jing Zhu,

Meng-Fan Xu

et al.

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2024

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Cited by 2 publications

References 48 publications

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Facile synthesis and polymerization of 1,4,5-oxadithiepan-2-one for disulfide-based redox-responsive drug delivery

Chakraborty,

Sengupta,

Bhattacharyya

et al. 2024

Polymer

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Facile synthesis and polymerization of 1,4,5-oxadithiepan-2-one for disulfide-based redox-responsive drug delivery

Chakraborty,

Sengupta,

Bhattacharyya

et al. 2024

Polymer

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Stimulus-Responsive Hydrogels for Targeted Cancer Therapy

Solanki,

Bhatia

2024

Gels

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Cancer is a highly heterogeneous disease and remains a global health challenge affecting millions of human lives worldwide. Despite advancements in conventional treatments like surgery, chemotherapy, and immunotherapy, the rise of multidrug resistance, tumor recurrence, and their severe side effects and the complex nature of the tumor microenvironment (TME) necessitates innovative therapeutic approaches. Recently, stimulus-responsive nanomedicines designed to target TME characteristics (e.g., pH alterations, redox conditions, enzyme secretion) have gained attention for their potential to enhance anticancer efficacy while minimizing the adverse effects of chemotherapeutics/bioactive compounds. Among the various nanocarriers, hydrogels are intriguing due to their high-water content, adjustable mechanical characteristics, and responsiveness to external and internal stimuli, making them promising candidates for cancer therapy. These properties make hydrogels an ideal nanocarrier for controlled drug release within the TME. This review comprehensively surveys the latest advancements in the area of stimulus-responsive hydrogels for cancer therapy, exploring various stimuli-responsive mechanisms, including biological (e.g., pH, redox), chemical (e.g., enzymes, glucose), and physical (e.g., temperature, light), as well as dual- or multi-stimuli responsiveness. Furthermore, this review addresses the current developments and challenges in hydrogels in cancer treatment. Our aim is to provide readers with a comprehensive understanding of stimulus-responsive hydrogels for cancer treatment, offering novel perspectives on their development for cancer therapy and other medical applications.

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One-pot preparation of pH- and redox-responsive polymeric microgel as an efficient carrier for improved breast cancer therapy

Cited by 2 publications

References 48 publications

Facile synthesis and polymerization of 1,4,5-oxadithiepan-2-one for disulfide-based redox-responsive drug delivery

Facile synthesis and polymerization of 1,4,5-oxadithiepan-2-one for disulfide-based redox-responsive drug delivery

Stimulus-Responsive Hydrogels for Targeted Cancer Therapy

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