One-Pot, Pseudo Four-Component Synthesis of a Spiro[diindeno[1,2-b:2′,1′-e]pyridine-11,3′-indoline]-trione Library

Abstract

A one-pot, pseudo four-component method for the efficient and simple synthesis of spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-2',10,12-trione derivatives in refluxing acetonitrile is reported. The features of this procedure are mild reaction conditions, high yields of products, and operational simplicity.

Recent Advances in Green Synthesis of 3,3′‐Spirooxindoles via Isatin–based One–pot Multicomponent Cascade Reactions in Aqueous Medium

“…Khazaei [50] reported an eco-friendly one-pot method for the synthesis of spiro-oxindoles derivatives in aqueous medium catalyzed by N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e] [1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide (DCDBTSD) (Scheme 17). Spiro-pyran-oxindoles (60,61), as well as spiropyrazoline-oxindoles (62) were synthesized via this one-pot multicomponent reaction at 80 8C in water. A primary noticeable feature of Khazaei's method was that the water was not only used as reaction medium, but also used as the medium for the synthesis of DCDBTSD.…”

A Novel Method for the Synthesis of Spiro[indoline‐Pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]triones by Alum as a Reusable Catalyst

“…In continuation of our previous works for the synthesis of heterocyclic compounds [25–30], recently, we reported novel one‐pot, three‐component synthesis of spiro[indoline‐pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]trione in refluxing condition at 24 h [31]. Herein, we report a simple and efficient method for the synthesis of these spirooxindoles with fused pyrazole, pyridine, and pyrimidine rings, through the three‐component one‐pot reaction in ionic liquid media, using Alum as a catalyst at very short reaction times.…”

Highly efficient synthesis of benzopyranopyrimidine derivatives catalyzed by functionalized superparamagnetic graphene oxide as a new and recoverable catalyst

“…In continuation of our ongoing efforts towards to develop efficient catalysts for different MCRs [4] ,We report herein functionalized superparamagnetic graphene oxide as a new and heterogeneous catalyst for the synthesis of benzopyranopyrimidine derivatives in high yields via a one-pot, pseudo four-component condensation of salicylaldehydes, malononitrile and secondary amines under mild conditions at room temperature. [5][6] (Scheme1). It should be noted that the significant advantages of this procedure are low catalyst loading, short reaction times, high to excellent yields, simple workup, reusability of the catalyst and simple purification of the products (table1).…”