One-pot reaction of pyranoindolones with phenylisocyanates: a simple and regioselective approach to β-carbolines

Lewis Acid Assisted Brønsted Acid Catalysed Decarbonylation of Isocyanates: A Combined DFT and Experimental Study

“…The ability of the borane-water adduct to donate a proton is as strong as HCl (pK a = 8.4/8.5 in MeCN). [7] Isocyanates are known to be reactive electrophiles [8] which undergo a range of reactions with various nucleophiles, such as amines to produce carbodiimides, [9][10][11] as exemplified by the hydroamination of isocyanates which produces functionalised urea derivatives. [12][13][14] This class of scaffolds has been identified as important building blocks towards pharmaceuticals, [15] agrochemicals, [16] and in materials chemistry.…”