One-Pot Regiodirected Annulations for the Rapid Synthesis of π-Extended Oligomers

Nitti, Andrea; Osw, Peshawa; Calcagno, Giuseppe; Botta, Chiara; Etkind, Samuel I.; Bianchi, Gabriele; Pò, Riccardo; Swager, Timothy M.; Pasini, Dario

doi:10.1021/acs.orglett.0c01043

Cited by 32 publications

(24 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, synthetic access to this scaffold remains relevant as can be seen from recent works in carbonylation, 26 in carbocyclization, [27][28][29] direct functionalization 30,31 or in annulation of thiophene heterocycles. [32][33][34][35] Therefore, the present study has been done to explore the possible functionalization of aminothiaindanone scaffold with three diversity points: first on the thiophene ring, second on the amine group, and finally third on the ketone part of the scaffold.…”

Section: Aminothiaindanone As An Accessible Scaffold For a Three-point Chemical Diversitymentioning

confidence: 99%

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Zipfel¹,

Lalut²,

Santos³

et al. 2021

Synthesis

View full text Add to dashboard Cite

Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. In order to increase the chemical diversity in this series, we explored the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold. About thirty newly functionalized thiophene-containing bicycles have been obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.

show abstract

Section: Aminothiaindanone As An Accessible Scaffold For a Three-point Chemical Diversitymentioning

confidence: 99%

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Zipfel¹,

Lalut²,

Santos³

et al. 2021

Synthesis

View full text Add to dashboard Cite

show abstract

“…Several researchers focused on progresses in catalysis and reaction engineering that conducted to waste and energy reduction for techniques that remain constitute important dares [2]. Some scientists concentrated on usage of less toxic reagents, catalysts, or routes [60][61][62]. In terms of catalysis front, there is an augmentation in the field of synthetic transformations assisted by supported catalysts [63,64].…”

Section: Reducing the Effect Of Chemical Synthesis And Manufacturingmentioning

confidence: 99%

Green Chemistry and Process Intensification: Milestones on a Sustainable Development

Ghernaout

Elboughdiri

Lajimi

2021

View full text Add to dashboard Cite

As a philosophical support, green chemistry (GC) becomes at present well-combined into the scientific system to assist scientists and engineers consider how to decrease or remove waste and avert the employment and formation of hazardous substances in the design phase of chemicals. Such design attempts in turn affect the full life-cycle of the chemical, from getting the starting materials until the end-use product is recycled or disposed of. There is a considerable advance noted in such direction during the last three decades, this review focuses on GC research. As a comparatively fresh technique, revision in process intensification (PI) is fast and investigation could rapidly lead to outstanding outcomes. However, numerous features of PI could take more time to be fact. Much of the study stays in academic and industrial laboratories, even if large-scale implementations of micro-reactors are actuality. Fields of PI enterprise that have progressed quickly are the expansion of carbon capture techniques, an increasing interest in GC, and the beginning of momentous study into connecting solar energy to intensified methods like chemical reactions. Electric fields (e.g., microwaves and ultrasound) are observed in larger usages, and the application of electrokinetic forces at the micro- and nanoscale persist to fascinate. Huge investigations are working for the sake of ideas like the perfect reactor. PI remains a motif leading to attain a sustainable society. This work may be an orientation in the investigation of product development and design, production and application, in a constructive and stimulating way.

show abstract

“…Monomers with a fused aromatic structure can be synthesized via direct arylation and subsequent cyclization reactions. [ 42–45 ] Indacenodithiophene (IDT) is a promising building block for conjugate polymers; [ 46 ] however, its tedious synthetic pathway is a drawback. Introduction of thiophene units by direct arylation and double cyclization offers a straightforward route for the preparation of IDT derivatives ( Scheme ).…”

Section: Monomer Synthesis Via Direct Ch Arylation and Subsequent Direct Arylation Polycondensationmentioning

confidence: 99%

Step‐Economical Synthesis of Conjugated Polymer Materials Composed of Three Components: Donor, Acceptor, and π Units

Kuwabara

Kanbara

2020

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Conjugated polymers have immense potential for their use as semiconducting materials in organic optoelectronic devices. The improvement of synthetic methods for conjugated polymers is important for the practical application of conjugated polymers. For mass production, synthetic methods must be developed by considering the concerns regarding cost and environment. Reduction in the number of synthetic steps is an efficient approach to address these concerns. The utilization of direct CH functionalization is a reasonable strategy in monomer and polymer syntheses, because the prefunctionalization steps for CC bond formation can be eliminated. This review summarizes the recent developments in the efficient syntheses of conjugated polymers as well as their monomers via direct arylation (CH/CX coupling) and cross‐dehydrogenative coupling (CH/CH coupling) reactions.

show abstract

One-Pot Regiodirected Annulations for the Rapid Synthesis of π-Extended Oligomers

Cited by 32 publications

References 42 publications

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Green Chemistry and Process Intensification: Milestones on a Sustainable Development

Step‐Economical Synthesis of Conjugated Polymer Materials Composed of Three Components: Donor, Acceptor, and π Units

Contact Info

Product

Resources

About