One-Pot Synthesis and Antibacterial Activities of Novel 1H-Pyridazino[1,2-a]indazole-1,6,9(2H,11H)-triones

Abstract

Synthesis of novel 1H-pyridazino[1,2-a]indazole-1,6,9(2H,11H)-triones using one-pot, three components reaction of 1,2-dihydropyridazine-3,6-dione, dimedone and aldehydes under solvent-free conditions has been reported. These products were evaluated in vitro for their antibacterial activities.

InCl3-catalyzed efficient synthesis of spiro-perimidine derivatives

“…Due to the biological activity of perimidine derivatives, and our interest in the synthesis of heterocyclic compounds [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31], herein, we report a simple and efficient method for the preparation of spiro-perimidines in water. In fact, as clearly stated by Sheldon [32], it is generally recognized that ''the best solvent is no solvent and if a solvent (diluent) is needed it should preferably be water''.…”

SnO2 nanoparticles as an efficient heterogeneous catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones

“…The solvent was removed under vacuum to get the crude product, which on further recrystallization with ethanol afforded the pure product (compared with literatures Ref. [16][17][18][26][27][28]). The pure products were characterized with FT-IR, 1 H and 13 C NMR spectroscopic techniques.…”

“…In recent years, the literature reports reveal that only a limited number of solvent-free protocols are available for the synthesis of phthalazine derivatives using the condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes with various catalysts [16][17][18][19][20][21][22][23][24][25]. However, the reported methods have some limitations such as nonbiodegradable and expensive metal catalysts, corrosive reaction media and longer reaction times due to which new synthetic protocols may be suggested for the synthesis of phthalazine derivatives via one-pot multicomponent reactions.…”

Ionic Liquid Catalyzed One‐Pot Synthesis of 2H‐Pyridazino[1,2‐a]indazole‐1,6,9(11H)‐triones Via Three‐Component Reaction under Solvent‐Free Conditions

“…Recently the synthesis of 2 H ‐pyridazino[1,2‐ a ]indazole‐1,6,9(11 H )‐triones has been reported by Bazgir and Teimouri using p ‐TSA as catalyst . However, the method has various drawbacks: low yields, the use of expensive catalyst and non‐recyclability.…”