One‐Pot Synthesis and Characterization of Some New Types of 5,5′‐Disubstituted Bis(imidazolidine‐2,4‐diones)

Abstract

The synthesis and structural elucidation of some novel 5,5′‐disubstituted spiro and nonspiro‐bis‐hydantoins are reported. The Bucherer Burge's method has been modified for the preparation of some 5,5′‐substituted bis(imidazolidine‐2,4‐dione) derivatives starting with diketones (1–5) and dialdehydes (6, 7). In some cases, diastereoisomeric mixtures of compounds were obtained. The resulting bis‐hydantoins (8–11, 13, 14) have not to our knowledge been previously reported in the literature.

Practical one-pot synthesis of semicarbazone derivatives via semicarbazide, and evaluation of their antibacterial activity

“…In the other attempt in contribution to our previous bis-synthesis [38][39][40][41], 0.5 equivalents of prepared diketone 7, upon reaction with one equivalent of 5 and one equivalent of H 2 N-NH 2 ÁH 2 O via in situ prepared intermediate 8, in one pot led to the formation of 2,2 0 -(((butane-1,4-diylbis(oxy))bis(3,1-phenylene))bis(ethan-1-yl-1-ylidene))bis(N-phenylhydrazine-1-carboxamide) 9 (Scheme 3).…”

Two- and Three-Directional Synthesis by 3-7MCRs of Novel (Imidazolidine/Thiazolidine)-2,4-Diones: Characterization, Antibacterial, Anticonvulsant and Molecular Docking Investigation

“…The precipitated product was ltered, washed with H 2 O, dried, and recrystallized from EtOH to give a solid. The reaction was shown in Scheme 1 [41].…”

“…The synthesis of the 2 [41] was obtained according to method B (Scheme 1) as a cream-powder with a high yield. The structure of 2 was con rmed by FT-IR, 1 HNMR, 13 CNMR, and Elemental analysis (C, H, O, and N).…”

One‐pot Synthesis of Novel 2,8‐dithioxopyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1H)‐dione Catalyzed by p‐Toluenesulfonic Acid

“…Here in contribution to our previous synthetic efforts , we describe one‐pot three components synthesis of 5‐substituted‐2,8‐dithioxo‐2,3,5,7,8,9‐hexahydro‐4 H ‐pyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1 H )‐dione derivatives via reaction of various aldehydes and thiobarbituric acid derivatives in the presence of p ‐toluenesulfonic acid ( p ‐TSA) as catalyst in EtOH under reflux condition. Recently, the application of microwaves and ultrasound in synthesis is very popular because they frequently proceed greatly faster and carry products in higher yield and ultrapurity.…”