One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola

Anadozie, Scholastica Onyebuchi; Adewale, Olusola Bolaji; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Isitua, Chinwe C.; Davids, Hajierah; Roux, Saartjie

doi:10.1016/j.procbio.2023.02.010

Cited by 11 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metal nanoparticles (NPs), such as silver and gold, have gained researchers’ attention as potential nanoproducts that find imperative applications in biomedicine ( Hawsawi et al, 2023 ; Nath et al, 2023 ; Sukri et al, 2023 ). On the ground of medical applications of silver and gold nanoparticles, there are various reports on antibacterial investigations ( Rasheed et al, 2017 ; Nath et al, 2020 ; Wypij et al, 2021 ; Singh and Mijakovic, 2022 ; Raja et al, 2023 ), antifungal activities ( AlMasoud et al, 2020 ; Leyu et al, 2023 ), anticancer studies ( Gomathi et al, 2020 ; Kumari et al, 2020 ; Nath et al, 2020 ; Anadozie et al, 2023 ; Moosavy et al, 2023 ; Raja et al, 2023 ), antioxidant evaluations ( Rasheed et al, 2017 ; Leyu et al, 2023 ; Moosavy et al, 2023 ), wound healing studies ( Aldakheel et al, 2023 ), anthelmintic activity ( Majumdar and Kar, 2023 ), and anti-inflammatory and analgesic activities ( Ahmad et al, 2015 ). On the other hand, the chemicals employed in the fabrication of nanomaterials are expensive but also toxic and hazardous to human life and the environment ( Dehvari and Ghahghaei, 2018 ; Rahimi and Doostmohammadi, 2019 ; Altammar, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

Nath,

Shyanti,

Singh

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

The present study investigated the synthesis and biological applications of green, economical, and multifunctional silver and gold nanoparticles (TSAgNPs and TSAuNPs) using the ethnomedical important medicinal plant Thespesia lampas for biological activities. Relatively higher levels of antioxidant components were measured in T. lampas compared to the well-known Adhatoda vasica, and Diplocyclos palmatus suggested the potential of T. lampas for the study. Synthesized TSAgNPs and TSAuNPs were characterized through UV–Vis, XRD, SEM-EDS, HR-TEM, SAED, and FTIR techniques. SEM revealed that TSAgNPs and TSAuNPs were predominantly spherical in shape with 19 ± 7.3 and 43 ± 6.3 nm crystal sizes. The sizes of TSAgNPs and TSAuNPs were found to be12 ± 4.8 and 45 ± 2.9 nm, respectively, according to TEM measurements. The FTIR and phytochemical analyses revealed that the polyphenols and proteins present in T. lampas may act as bio-reducing and stabilizing agents for the synthesis. Synthesized NPs exhibited enhanced scavenging properties for ABTS and DPPH radicals. TSAgNPs and TSAuNPs were able to protect DNA nicking up to 13.48% and 15.38%, respectively, from oxidative stress. TSAgNPs possessed efficient antibacterial activities in a concentration-dependent manner against human pathogenic bacteria, such as E. coli, B. subtilis, P. vulgaris, and S. typhi. Furthermore, TSAgNPs and TSAuNPs showed significant cytotoxicity against FaDu HNSCC grown in 2D at 50 and 100 μg mL−1. Tumor inhibitory effects on FaDu-derived spheroid were significant for TSAgNPs > TSAuNPs at 100 μg mL−1 in 3D conditions. Dead cells were highest largely for TSAgNPs (76.65% ± 1.76%), while TSAuNPs were non-significant, and Saq was ineffectively compared with the control. However, the diameter of the spheroid drastically reduced for TSAgNPs (3.94 folds) followed by TSAuNPs (2.58 folds), Saq (1.94 folds), and cisplatin (1.83 folds) at 100 μg mL−1. The findings of the study suggested the bio-competence of TSAgNPs and TSAuNPs as multi-responsive agents for antioxidants, DNA protection, antibacterial, and anti-tumor activities to provide a better comprehension of the role of phytogenic nanoparticles in healthcare systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

Nath,

Shyanti,

Singh

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Cancer is a significant global health issue with second leading cause of death worldwide. About 19.3 million fresh cancer cases and 10 million cancer‐related deaths were reported globally in 2020 (Sung et al, 2021; Yan et al, 2024), which and it is expected that by 2040, there could be 28.9 million new cancer cases and 16.2 million cancer‐related deaths annually (Anadozie et al, 2023; Gao et al, 2021). The rising mortality rate related to cancer necessitates urgent attention in disease management (Hammami & Alabdallah, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Gold nanoparticles (AuNPs) have garnered significant consideration in the biomedical field because of their unique physicochemical properties, including tunable biocompatibility, surface chemistry, shape, and size (Li et al, 2019). These nanoparticles find versatile uses in various areas such as photodynamic therapy, drug delivery, bio‐sensing, bio‐imaging, bio‐labelling, and even as therapeutic agents for cancer (Anadozie et al, 2023). The synthesis of AuNPs involves different approaches, including physical, chemical, and biological methods.…”

Section: Introductionmentioning

confidence: 99%

Shining insights: Deciphering the biogenic synthesis of Ajuga bracteosa‐mediated gold nanoparticles with advanced microscopy techniques

Afreen,

Hameed,

Tariq

et al. 2024

Microscopy Res & Technique

View full text Add to dashboard Cite

In this study, gold nanoparticles (AuNPs) were bioreduced from Ajuga bracteosa, a medicinal herb known for its therapeutic properties against various diseases. Different fractions of the plant extract were used, including the methanolic fraction (ABMF), the n‐hexane fraction (ABHF), the chloroform fraction (ABCF), and the aqueous extract for AuNPs synthesis. The characterization of AuNPs was performed using UV–Vis spectrophotometry, FT‐IR, XRD, EDX, and TEM. UV–Vis spectroscopy confirmed the formation of AuNPs, with peaks observed at 555 nm. FT‐IR analysis indicated strong capping of phytochemicals on the surface of AuNPs, which was supported by higher total phenolic contents (TPC) and total flavonoid contents (TFC) in AuNPs. XRD results showed high crystallinity and a smaller size distribution of AuNPs. TEM analysis revealed the spherical shape of AuNPs, with an average size of 29 ± 10 nm. The biologically synthesized AuNPs exhibited superior antibacterial, antioxidant, and cytotoxic activities compared to the plant extract fractions. The presence of active biomolecules in A. bracteosa, such as neoclerodan flavonol glycosides, diterpenoids, phytoecdysone, and iridoid glycosides, contributed to the enhanced biological activities of AuNPs. Overall, this research highlights the potential of A. bracteosa‐derived AuNPs for various biomedical applications due to their remarkable therapeutic properties and effective capping by phytochemicals.Research Highlights This research underscores the growing significance of herbal medicine in contemporary healthcare by exploring the therapeutic potential of Ajuga bracteosa and gold nanoparticles (AuNPs). The study highlights the notable efficacy of A. bracteosa leaf extracts and AuNPs in treating bacterial infections, demonstrating their bactericidal effects on a range of strains. The anti‐inflammatory properties of plant extracts and nanoparticles are evidenced through paw edema method suggesting their applicability in managing inflammatory conditions. These findings position A. bracteosa and AuNPs as potential candidates for alternative and effective approaches to modern medication.

show abstract

“…Furthermore, plant phytochemicals can not only be loaded onto NPs to assist their delivery to the target sites or to improve their pharmacokinetics, but also can be involved in the biosynthesis of NPs as a way of lowering the toxicity of the NPs to be suitable for biomedical applications [23]. The conventional physical and chemical methods for synthesizing NPs involve the use of toxic and hazardous chemicals such as sodium/potassium borohydrate, hydrazine, sodium citrate, and salts of tartrate, which require high energy consumption, are expensive, and involve complex techniques [24,25]. In contrast, the green biosynthesis of NPs offers an easy, convenient, scalable, and eco-friendly alternative that requires less energy [26].…”

Section: Introductionmentioning

confidence: 99%

Reports of Plant-Derived Nanoparticles for Prostate Cancer Therapy

Elbagory

Hull

Meyer

et al. 2023

Plants

View full text Add to dashboard Cite

Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of these phytochemicals into the market as anticancer agents has been hindered by their poor bioavailability, mainly due to their inadequate aqueous solubility, chemical instability, and unsatisfactory circulation time. To overcome these drawbacks, it has been suggested that the incorporation of phytochemicals as nanoparticles can offer a solution. The use of plant-based chemicals can also improve the biocompatibility of the formulated nanoparticles by avoiding the use of certain hazardous chemicals in the synthesis, leading to decreased toxicity in vivo. Moreover, in some cases, phytochemicals can act as targeting agents to tumour sites. This review will focus on and summarize the following points: the different types of nanoparticles that contain individual phytochemicals or plant extracts in their design with the aim of improving the bioavailability of the phytochemicals; the therapeutic evaluation of these nanoparticles against prostate cancer both in vitro and in vivo and the reported mode of action and the different types of anticancer experiments used; how the phytochemicals can also improve the targeting effects of these nanoparticles in some instances; and the potential toxicity of these nanoparticles.

show abstract

One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola

Cited by 11 publications

References 62 publications

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

Shining insights: Deciphering the biogenic synthesis of Ajuga bracteosa‐mediated gold nanoparticles with advanced microscopy techniques

Reports of Plant-Derived Nanoparticles for Prostate Cancer Therapy

Contact Info

Product

Resources

About