One‐pot synthesis of 2‐amino‐4,8‐dihydropyrano[3,2‐b]pyranes and pyridopyrimidines under mild conditions

Abstract

1,8‐Diazabicyclo[5.4.0]undec‐7‐ene immobilized on silica (SB‐DBU)Cl as a reusable and heterogeneous catalyst was applied for the one‐pot, three‐component synthesis of 2‐amino‐4,8‐dihydropyrano[3,2‐b]pyrane‐3‐carbonitriles and pyridopyrimidines, under solvent‐free conditions. The reaction was carried out at room temperature, and pure products were obtained in high yields and short reaction times (3–7 min). This work introduced an environmentally benign procedure for the synthesis of these classes of biological active compounds.

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

“…In 2016, a straightforward and environmentally conscious green procedure was employed to synthesize pyrazolo‐pyrano‐pyrimidines 16 through a four‐component reaction involving aromatic aldehydes 1 , hydrazine hydrate 2 , ethyl acetoacetate 3 , and barbituric acid or dimethyl barbituric acid 8 by Shaterian and their coworkers [80] . This reaction took place under thermal and solvent‐free conditions, utilizing a magnetic nanoparticle supported catalyst (MNPs@DABCO + Cl − ) that exhibited high efficiency and could be easily recycled due to its heterogeneous nature (Table 10).…”

Design and synthesis of ferrocene‐based magnetic nanoparticle and investigation of its catalytic ability in the synthesis of novel 6‐[(morpholin‐4‐yl)methyl] substituted pyrano[3,2‐b]pyran derivatives

“…[ 23–31 ] In addition, these derivatives are suitable drugs for the treatment of disorders like Alzheimer's, myoclonus, and schizophrenia. [ 32 ] In literature, various catalytic systems including MCM‐41‐SO 3 H, [ 33 ] Et 3 N in the ionic liquid [bmim]BF 4 , [ 34 ] β ‐CD, [ 35 ] (SB‐DBU)Cl, [ 36 ] Fe 3 O 4 @SiO 2 ‐IL‐Fc, [ 37 ] Si‐Mg‐FA, [ 38 ] and SiO 2 @Imid‐Cl@Fc [ 39 ] have been reported for pyran derivatives synthesis. In this research work, we designed and synthesized the Fe 3 O 4 @SiO 2 @(CH 2 ) 3 ‐Im‐bisethylFc (CH 3 CO 2 ) as a new catalyst, which is a silica‐coated Fe 3 O 4 NP supported with bisethylferrocene‐containing IL.…”

“…[23][24][25][26][27][28][29][30][31] In addition, these derivatives are suitable drugs for the treatment of disorders like Alzheimer's, myoclonus, and schizophrenia. [32] In literature, various catalytic systems including MCM-41-SO 3 H, [33] Et 3 N in the ionic liquid [bmim]BF 4 , [34] β-CD, [35] (SB-DBU)Cl, [36] Fe 3 O 4 @SiO 2 -IL-Fc, [37] Si-Mg-FA, [38] and SiO 2 @Imid-Cl@Fc [39] have been reported for pyran derivatives synthesis. In this research work, we designed and synthesized the Fe pyran-4-one, malononitrile, and diversity of aromatic aldehydes.…”

Green synthesis of new thiouracilodepsipeptides in ionic liquid: One‐pot four‐component reaction of isocyanides

“…[6,7] Among them, the Passerini three component reaction (P-3CR) and the U-4CR are the most famous. [11,12] The expansion of MCRs in the presence of task-specific ILs, employed not only as environmentally benign reaction media, but also as catalysts, is a new approach that meets the requirements of sustainable chemistry. [9,10] The rising significance of RTILs is associated with their desirable properties.…”