One-pot synthesis of 2-aminobenzoxazole derivatives using acetic acid as an electrolyte under electrochemical conditions

Electrochemical synthesis of 4-quinazolinone derivatives mediated by acetic acid

“…In earlier work, we synthesized benzoxazoles, benthiazoles and benzimidazoles by using aluminum and carbon as the electrode system, acetic acid as an electrolyte and acetonitrile/methanol as the solvent. [16][17][18] Performing research on similar lines we electrochemically reacted benzaldehyde (1a) and 2-aminobenzamide (2a) in acetonitrile and after 3 h obtained 41% conversion (as per LCMS analysis). Encouraged by this result we screened a number of solvents (as listed in Table-1).…”