One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents

Tomane, Somia; López‐Maya, Elena; Boujday, Souhir; Humblot, Vincent; Marrot, Jérôme; Rabasso, Nicolas; Castells‐Gil, Javier; Sicard, Clémence; Dolbecq, Anne; Vallée, Anne

doi:10.1039/c9na00401g

Cited by 15 publications

(20 citation statements)

References 55 publications

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“…As a good example of nanotherapeutics against biofilms, it is the application of polyoxometalates (POMs) supported by gold nanoparticles (AuNPs) on P. aeruginosa and Staphylococcus biofilms, which have been shown to have a potent effect in the inhibition of biofilms. This was attributed to the fact that AuNPs can induce a disruption of cell membrane integrity, leading to bacterial cell death [ 126 ].…”

Section: Antibacterial and Antibiofilm Strategiesmentioning

confidence: 99%

The Two Weapons against Bacterial Biofilms: Detection and Treatment

et al. 2021

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Bacterial biofilms are defined as complex aggregates of bacteria that grow attached to surfaces or are associated with interfaces. Bacteria within biofilms are embedded in a self-produced extracellular matrix made of polysaccharides, nucleic acids, and proteins. It is recognized that bacterial biofilms are responsible for the majority of microbial infections that occur in the human body, and that biofilm-related infections are extremely difficult to treat. This is related with the fact that microbial cells in biofilms exhibit increased resistance levels to antibiotics in comparison with planktonic (free-floating) cells. In the last years, the introduction into the market of novel compounds that can overcome the resistance to antimicrobial agents associated with biofilm infection has slowed down. If this situation is not altered, millions of lives are at risk, and this will also strongly affect the world economy. As such, research into the identification and eradication of biofilms is important for the future of human health. In this sense, this article provides an overview of techniques developed to detect and imaging biofilms as well as recent strategies that can be applied to treat biofilms during the several biofilm formation steps.

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Section: Antibacterial and Antibiofilm Strategiesmentioning

confidence: 99%

The Two Weapons against Bacterial Biofilms: Detection and Treatment

et al. 2021

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“…Another route consists in using a reduced polyoxovanadate functionalized with bisphosphonate molecules in order to prepare in a single step hybrid organic-inorganic polyoxometalate decorated gold nanoparticles. These new nanocomposites were shown to strongly inhibit P. aeruginosa and S. epidermidis biofilm growth (See Scheme 14) [121].…”

Section: Functionalization By Polyoxometalate Compounds (Pom)mentioning

confidence: 99%

“…This molecule exhibited a linker of sufficient length to induce a good control of the Scheme 14. Schematic representation of CitNPs, CitNPs@POVred and NPs@POV synthesis, reproduced with permission from [121], RSC 2019.…”

Section: Single Ferroncenyl Complexesmentioning

confidence: 99%

Functionalization of Gold Nanoparticles by Inorganic Entities

2020

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The great affinity of gold surface for numerous electron-donating groups has largely contributed to the rapid development of functionalized gold nanoparticles (Au-NPs). In the last years, a new subclass of nanocomposite has emerged, based on the association of inorganic molecular entities (IME) with Au-NPs. This highly extended and diversified subclass was promoted by the synergy between the intrinsic properties of the shell and the gold core. This review—divided into four main parts—focuses on an introductory section of the basic notions related to the stabilization of gold nanoparticles and defines in a second part the key role played by the functionalizing agent. Then, we present a wide range of inorganic molecular entities used to prepare these nanocomposites (NCs). In particular, we focus on four different types of inorganic systems, their topologies, and their current applications. Finally, the most recent applications are described before an overview of this new emerging field of research.

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“…20 In particular, they can play a significant role in the synthesis and the stabilization of Au NPs and also promote applications in numerous fields such as catalysis, biosensing and medicinal use 21 through their surface functionalization. For example, antibacterial activities of AuNPs functionalized with Keggintype POMs 22 or polyoxovanadate bisphosphonate molecules 23 POMs. The biostability of the resulting AuNP@Mo 4 Zol 2 Mn was evidenced in culture media, and the anticancer activity of this nanohybrid against PC3 human prostate adenocarcinoma cells was then investigated in the dark and under irradiation (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

“…25 The citrate anions were then exchanged with Mo 4 Zol 2 Mn (Scheme 1), as reported previously for the synthesis of AuNP functionalized with Keggin 26 or polyoxovanadate anions. 23 The excess of POM was removed by appropriate washing, affording the targeted AuNP@Mo 4 Zol 2 Mn nanohybrid. Figure 1a shows the UV-vis spectra of citAuNP and 2 provide the half maximal inhibitory concentration (IC 50 ) per zoledronate of each compound (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy–Photothermal Cancer Therapy

Tomane

Wilhelm

Boujday

et al. 2021

ACS Appl. Nano Mater.

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We designed monodisperse and perfectly shaped core/shell AuNP@Mo 4 Zol 2 Mn nanohybrids consisting of gold nanoparticles (AuNPs) functionalized by an antitumoral polyoxometalate (POM) incorporating the biologically active zoledronate ligand. After incubation, the nanoparticles were readily confined in the endosomal compartments of PC3 human prostate adenocarcinoma cells. Under photothermal treatment, the metabolic activity drastically decreased at concentrations where the nanohybrids exhibited no anticancer activity in the dark, and almost all cancer cells were killed at concentrations at which zoledronate alone was totally inactive. This study evidences for the first time that AuNPs capped by POMs can represent excellent candidates for combined chemotherapy and photothermal cancer therapy.

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One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents

Abstract: A reduced polyoxovanadate functionalized with alendronate molecules was used for the synthesis of gold nanoparticles; these hybrid nanomaterials exhibit high antibiofilm activity.

Cited by 15 publications

References 55 publications

The Two Weapons against Bacterial Biofilms: Detection and Treatment

The Two Weapons against Bacterial Biofilms: Detection and Treatment

Functionalization of Gold Nanoparticles by Inorganic Entities

Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy–Photothermal Cancer Therapy

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