One pot synthesis of amine-functionalized and angular-shaped superparamagnetic iron oxide nanoparticles for MR/fluorescence bimodal imaging application

Yoo, Donggeon; Lee, Chaedong; Seo, Bokyung; Piao, Yuanzhe

doi:10.1039/c6ra28495g

Cited by 14 publications

(12 citation statements)

References 48 publications

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“…The presence of alginate and doxorubicin in samples N52 and N52D was observed by the fine peaks between 1000 and 1600 cm −1 . Similar results were recorded in other studies [6,14] TEM and FESEM images (Figure 5 B-E) showed that the nanoparticles had a uniform size of about 20 nm. N52D nanoparticles with Doxorubicin appeared on the images with a surrounding polymer layer.…”

Section: Dependence Of Fluorescent Spectra On Drug Delivery Processsupporting

confidence: 91%

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Factors Affecting Fluorescent Intensity of Fe3o4-Cyanine 5.5 Nanoparticles

Phan

Ung

et al. 2022

Vietnam J. Sci. Technol.

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In this study, we examined the dependence of fluorescent intensity on different factors in the synthesis process of Fe3O4-cyanine 5.5 nanoparticles. The results showed that Fe3O4 nanoparticles needed to be covered with a layer of NH2 group before reacting with cyanine 5.5-NHS ester. The best cyanine 5.5 NHS ester:Fe3O4 and cyanine 5.5 NHS ester :APTES ratios were 1:20 and 1:3, respectively. The drug delivery did not affect much on the fluorescent property while increasing in excitation wavelength could lead to increase in fluorescent intensity of the system.

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Section: Dependence Of Fluorescent Spectra On Drug Delivery Processsupporting

confidence: 91%

“…Recently, fluorescent-magnetic nanoparticles have been well investigated for multimodal imaging applications [5,6]. In the studies, the near-infrared fluorescent fluorophore, cyanine 5.5 (Cy5.5), was used for labeling the presence of nanoparticles in cells.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Fluorescent Intensity of Fe3o4-Cyanine 5.5 Nanoparticles

Phan

Ung

et al. 2022

Vietnam J. Sci. Technol.

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“…The morphology of the particles is of equal importance as size in in vivo applications and has been shown to be altered by the addition of halide ions [ 101 ]. There have also been advancements in solvents, such as the thermostable ionic solvent [P6,6,6,14][Tf2N], which has been shown to be capable of synthesizing quasi spherical magnetite nanoparticles of around 14 nm [ 102 ].…”

Section: Methods For the Synthesis Of Ionpsmentioning

confidence: 99%

Magnetic Nanoparticles as MRI Contrast Agents

et al. 2020

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Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.

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“…Such low Ms value is attributed to the diamagnetic contribution of the silica shell, which consists large portion of core-shell nanoparticles 30 . To investigate the MR imaging performance of NF-SIONs, phantom test was conducted following the previously reported method 31 . As plotted in Fig.…”

Section: Resultsmentioning

confidence: 99%

In vivo delineation of glioblastoma by targeting tumor-associated macrophages with near-infrared fluorescent silica coated iron oxide nanoparticles in orthotopic xenografts for surgical guidance

Lee

Kim

Yoon

et al. 2018

Sci Rep

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Glioblastoma multiforme (GBM) is the most aggressive and lethal type of human brain cancer. Surgery is a current gold standard for GBM treatment but the complete surgical resection of GBM is almost impossible due to their diffusive characteristics into surrounded normal brain tissues. There is an urgent need to develop a sensitive imaging tool for accurate delineation of GBM in the operating room to guide surgeons. Here we illustrate the feasibility of using near-infrared fluorescent silica coated iron oxide nanoparticles (NF-SIONs) with high water dispersion capacity and strong fluorescence stability for intraoperative imaging of GBM by targeting tumor-associated macrophages. Abundant macrophage infiltration is a key feature of GBM margins and it is well associated with poor prognosis. We synthesized NF-SIONs of about 37 nm to maximize endocytosis activity for macrophage uptake. The NF-SIONs selectively visualized tumor-associated macrophage populations by in vitro live-cell imaging and in vivo fluorescence imaging. In the orthotopic GBM xenograft models, the NF-SIONs could successfully penetrate blood-brain barrier and delineated tumor burden specifically. Taken together, this study showcased the potential applications in GBM treatment for improved intraoperative staging and more radical surgery as well as dual modality benefit in order to circumvent previous clinical failure.

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One pot synthesis of amine-functionalized and angular-shaped superparamagnetic iron oxide nanoparticles for MR/fluorescence bimodal imaging application

Abstract: Herein, we report the simple preparation of water dispersible angular-shaped amine-functionalized super-paramagnetic iron oxide nanoparticles (A-SPIONs).

Cited by 14 publications

References 48 publications

Factors Affecting Fluorescent Intensity of Fe3o4-Cyanine 5.5 Nanoparticles

Factors Affecting Fluorescent Intensity of Fe3o4-Cyanine 5.5 Nanoparticles

Magnetic Nanoparticles as MRI Contrast Agents

In vivo delineation of glioblastoma by targeting tumor-associated macrophages with near-infrared fluorescent silica coated iron oxide nanoparticles in orthotopic xenografts for surgical guidance

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