One-pot synthesis of amphiphilic superparamagnetic FePt nanoparticles and magnetic resonance imaging in vitro

Yang, Hong; Zhang, Jingjing; Tian, Qiwei; Hu, He; Fang, Yong; Wu, Huixia; Yang, Shiping

doi:10.1016/j.jmmm.2009.11.039

Cited by 59 publications

(39 citation statements)

References 42 publications

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“…Briefly, 1.5 mL oleylamine, 1.5 mL oleic acid, 0.1363 g iron acetylacetonate, and 100 mL anhydrous ethanol were mixed into three-necked round-bottomed flasks after 30 …”

Section: Synthesis Of Fept Npsmentioning

confidence: 99%

“…[27][28][29] Furthermore, compared to several commercial MRI/CT contrast agents, the superparamagnetic properties and X-ray absorption abilities of FePt NPs make them potential in vitro and in vivo dual-modality contrast agents (after surface engineering with functional molecules). [30][31][32][33] Based on the extremely high X-ray mass absorption coefficient of Pt, the hypothesis of the current study was that the NPs may increase the absorbed external beam dose in tumors, with decreased absorption of radiation in normal tissue and organs. Therefore, FePt NPs could be the precursor for CT, MRI, chemotherapy and radiotherapy all within one single agent, acting as a kind of multifunctional nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

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FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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Nanomaterials have an advantage in “personalized” therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray diffraction; transmission electron microscopy, Physical Property Measurement System, and Fourier transform infrared spectroscopy. The cytotoxicity of FePt NPs on Vero cells was assessed using an MTT assay, and tumor cell proliferation inhibited by individual FePt NPs and FePt NPs combined with X-ray beams were also collected using MTT assays; HeLa human cancer cell lines were used as in vitro models. Further confirmation of the combined effect of FePt NPs and X-rays was verified using HeLa cells, after which, the cellular uptake of FePt NPs was captured by transmission electron microscopy. The results indicated that the growth of HeLa cells was significantly inhibited by FePt NPs in a concentration-dependent manner, and the growth was significantly more inhibited by FePt NPs combined with a series of X-ray beam doses; the individual NPs did not display any remarkable cytotoxicity on Vero cells at a concentration <250 μg/mL. Meanwhile, the FePt NPs showed negative/positive contrast enhancement for MRI/CT molecule imaging at the end of the study. Therefore, the combined results implied that FePt NPs might potentially serve as a promising nanoprobe for the integration of tumor diagnosis and chemoradiotherapy.

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“…Briefly, 1.5 mL oleylamine, 1.5 mL oleic acid, 0.1363 g iron acetylacetonate, and 100 mL anhydrous ethanol were mixed into three-necked round-bottomed flasks after 30 …”

Section: Synthesis Of Fept Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…Magnetic property of FePt NP is dominated by its crystal structure, which is very essential for different magnetic applications. For example, chemically disordered FePt NPs showing typical superparamagnetic characteristics have been applied as novel multimodal molecular imaging contrast agents for cancer diagnosis [5][6][7]. In contrast, L1 0 -FePt NPs with extremely large magneto-crystalline anisotropy energy (MAE) are expected as a promising candidate for next generation data storage media and advanced permanent magnets [8,9].…”

Section: Introductionmentioning

confidence: 99%

Tuning crystal structure and magnetic property of dispersible FePt intermetallic nanoparticles

Gao

Liu

et al. 2018

Sci. China Mater.

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“…[16][17][18] The magnetization of FePt NPs up to ∼1000 emu cc −1 is higher than that of commonly used iron oxide (approximately 300-400 emu cc −1 ) and comparable to that of Co (∼1400 emu cc −1 ) and Fe (∼1700 emu cc −1 ), making them valuable candidates for magnetic resonance imaging. [19][20][21][22] It has been reported that FePt NPs display stronger contrast enhancement when compared with several commercial magnetic resonance imaging contrast agents (Feridex, MION, and Sinerem; AMAG Pharmaceuticals Inc., Lexington, MA, MGH Center of Molecular Imaging Research, Boston, MA, and Guerbet Group, Villepinte, France, respectively) according to their apparent transverse relaxivity values. 19,20 Therefore, FePt NPs can serve as dual modality contrast agents for molecular CT (computed tomography molecular imaging or MRI (magnetic resonance imaging) in vitro and in vivo after engineering their surfaces with functional molecules.…”

Section: Introductionmentioning

confidence: 99%

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Sun¹,

Chen²,

Chen³

et al. 2012

IJN

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Malignant gliomas are primary brain tumors with high rates of morbidity and mortality; they are the fourth most common cause of cancer death. Novel diagnostic and therapeutic techniques based on nanomaterials provide promising options in the treatment of malignant gliomas. In order to evaluate the potential of FePt nanoparticles (NPs) for malignant glioma therapy, FePt NPs with different surface coatings and components were tunably synthesized using oleic acid/oleylamine (OA/OA) and cysteines (Cys) as the capping agents, respectively. The samples were characterized using X-ray diffraction, transmission electron microscopy (TEM), X-ray photon spectroscopy, Fourier transform infrared spectroscopy, atomic absorption spectrum, and zeta potential. The influence of the surface coatings and components of the FePt NPs on the proliferation of glioma cells was assessed through MTT assay and TEM observation using three typical glioma cell lines (glioma U251 cells, astrocytoma U87 cells, and neuroglioma H4 cells) as in vitro models. The results showed that the proliferation of glioma cells was significantly suppressed by lipophilic FePt-OA/OA NPs in a time-and/or dose-dependent manner, while no or low cytotoxic effects were detected in the case of hydrophilic FePt-Cys NPs. The IC 50 value of FePt-OA/OA NPs on the three glioma cell lines was approximately 5-10 µg mL −1 after 24 hours' incubation. Although the cellular uptake of FePt NPs was confirmed regardless of the surface coatings and components of the FePt NPs, the suppression of FePt NPs on glioma cell proliferation was dominantly determined by their surface coatings rather than their components.Therefore, these results demonstrate that, through engineering of the surface coating, FePt NPs can potentially be developed as novel therapeutic agents for malignant gliomas.

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One-pot synthesis of amphiphilic superparamagnetic FePt nanoparticles and magnetic resonance imaging in vitro

Cited by 59 publications

References 42 publications

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Tuning crystal structure and magnetic property of dispersible FePt intermetallic nanoparticles

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

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