One Pot Synthesis of Cu(II) and Ni(II) Peroxo Complexes Containing Schiff Base: Physicochemical, Spectral and Antibacterial Investigations

Abstract

Two new peroxo complexes of Cu(II) and Ni(II) ion containing Schiff base (SB) were synthesized and characterized by TLC, Elemental analyses, conductivity, magnetic moment measurements, UV-Vis. and IR and ESI-MS spectral studies. The Schiff base ligand derived from cinnamaldehyde and o-aminophenol participated in complexation through a single pot reaction. IR spectra showed that the Schiff base ligand coordinated to the metal ion through nitrogen of azomethine group and oxygen of hydroxyl group & peroxo group (O-O). Magnetic moment value coupled with electronic spectral data suggested a square planar geometry for both the complexes. The molar conductance values indicated the non-electrolytic nature of the complexes. Antibacterial activity of the complexes was tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus & Bacillus cereus and two Gram-negative Escherichia coli & Shigella dysenteriae with Kanamycin (K-30) standard. The result shows that Cu(II) complex exhibited more potential antibacterial activity than the Ni(II) complex against all the tested organisms.

Synthesis, Characterization and Biological Activity of Oxovanadium(IV) Complexes Containing α-Amino Acid Schiff Bases and 5,6-Dimethyl-1,10-phenanthroline Ligands

“…[23,24] The complexes (50 µg / disc in DMSO solution) were screened for their antibacterial activity against four human pathogenic bacteria; two Gram positive Escherichia coli & Pseudomonas aeruginosa and two Gram negative Staphylococcus aureus & Bacillus cereus with Kanamycin (K-30) standard. [25][26][27][28] Overtone's concept and Tweedy's chelation theory can explain the greater activity of the complexes. [29] The significant antibacterial activity of metal complexes is due to the fact that only lipid-soluble materials making lipo-solubility, which is a main control factor for antibacterial activity.…”