One-pot synthesis of cyclodextrin-based radial poly[n]catenanes

Abstract

Supermolecules such as rotaxanes and catenanes have recently attracted considerable attention due to their potential widespread applications in areas such as molecular machines and switches. Moreover, the development of polyrotaxanes and polycatenanes, comprising multiple cyclic compounds, has allowed the fabrication of structures with novel properties. Although rotaxanes and polyrotaxanes have been extensively prepared from cyclodextrins as building blocks, very few studies have considered the syntheses of cyclodextrin-based polycatenanes. Here we report the one-pot syntheses and isolation of cyclodextrin-based radial polycatenanes with large numbers of cyclic components (>10) attached to a poly(ethylene glycol)–poly(propylene glycol)–poly(ethylene glycol) copolymer core, with characterization performed using Raman spectroscopy, gel permeation chromatography, 1H-NMR spectroscopy, and other techniques. Overall, the results presented herein may be used to develop advanced supramolecular structures and materials, such as molecular machines, molecular actuators, molecular switches, biomaterials, and drug carriers.

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

“…The polycatenanes obtained can be an advanced material for drug delivery and biomedical applications. [51]…”

“…Copyright 2006, Wiley‐VCH Verlag GmbH & Co. KgaAl. B) Reproduced with permission 51. Copyright 2019, Springer Nature.…”

“…In the formation process, oxidizing agent, H 2 O 2 was used to oxidize the thiol groups of PEG–PPG–PEG dithiol that cyclize disulfide bond formation results in the creation of polypseudorotaxane (polycatenanes). The polycatenanes obtained can be an advanced material for drug delivery and biomedical applications 51…”

Green chemistry and coronavirus

“…Xia et al . (2019) described a PDMS-ZnO nanorod microfluidics chip that was based on a smartphone for POC, rapid, low-cost and sensitive colorimetric detection of viruses in samples within 1.5 h ( Higashi et al, 2019 ). The channels of these nanostructures were made up of PDMS, and the ZnO nanorods were embedded in the channel walls, which enhanced the capture of the virus and improved the detection sensitivity.…”

Synthetic strategies towards mechanically interlocked oligomers and polymers

“…38). 149 3.4.3 Clipping. The clipping approach to mechanically interlocked polymers involves the cyclisation of macrocycle precursors around a pre-formed axle/macrocycle.…”