One‐Pot Synthesis of Functional Helicoidal Hybrid Organic–Inorganic Nanofibers with Periodically Organized Mesoporosity

Rambaud, Frédéric; Vallé, Karine; Thibaud, Simon; Julián‐López, Beatriz; Sánchez, Clément

doi:10.1002/adfm.200900431

Cited by 57 publications

(34 citation statements)

References 68 publications

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“…It offers high specific surface areas, large pore volumes and tunable pore sizes with narrow pore size distributions to allow high cargo loading. Nanoporous silica nanoparticles (NPSNPs), in particular, are of great interest to drug delivery, because their size [27][28][29], shape [30][31][32][33][34][35] and surface modification [36][37][38] can be adjusted. NPSNPs can easily be synthesized via the sol-gel route with surfactants as structure-directing agents [39].…”

Section: Introductionmentioning

confidence: 99%

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

Fullriede¹,

Abendroth²,

Ehlert

et al. 2016

BioNanoMaterials

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Abstract:A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nano porous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, the polymer serves as gate keeper blocking the pore openings to prevent the release of cargo molecules. At acidic pH values as they can occur during a bacterial infection, the polymer strains become protonated and straighten up due to electrostatic repulsion. The pores are opened and the cargo is released. The drug chlorhexidine was loaded into the pores because of its excellent antibacterial properties and low tendency to form resistances. The release was performed in PBS and diluted hydrochloric acid, respectively. The results showed a considerably higher release in acidic media compared to neutral solvents. Reversibility of this pHdependent release was established. In vitro tests proved good cytocompatibility of the prepared nanoparticles. Antibacterial activity tests with Streptococcus mutans and Staphylococcus aureus revealed promising perspectives of the release system for biofilm prevention. The developed polymer-modified silica nanoparticles can serve as an efficient controlled drug release system for long-term delivery in biomedical applications, such as in treatment of biofilm-associated infections, and could, for example, be used as medical implant coating or as components in dental composite materials.

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Section: Introductionmentioning

confidence: 99%

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

Fullriede¹,

Abendroth²,

Ehlert

et al. 2016

BioNanoMaterials

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show abstract

“…[1,2] Inspired by these architectures, materials chemists have prepared similar morphologies in the lab, for example by the application of templated sol-gel methods. [3] Interestingly, helical materials can be prepared in the absence of other chiral directors, for example using achiral surfactants, [4][5][6][7][8][9][10] but these techniques lead to equal amounts of both helical forms. For non-racemic helical structures, specially designed chiral, enantiomerically enriched surfactants are required.…”

mentioning

confidence: 99%

The Synthesis of Chiral Periodic Organosilica Materials with Ultrasmall Mesopores

Blackburn

Webb

et al. 2011

Angew Chem Int Ed

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Helical organosilica materials were synthesized for the first time using a novel binaphthyl-based chiral co-monomer in less than 1 hour. The incorporation of a chiral co-monomer in the wall was shown to influence the curvature of the helical materials. As the amount of the chiral co-monomer was increased, the degree of curvature increased, illustrating the importance of this monomer to the overall morphology.

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“…Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 7/4/15 5:35 AM Fabrication Synthesis of anisotropic nanoporous silica nanoparticles: Nanoporous silica nanoparticles with fiber-like morphology were obtained according to a procedure described in the literature [22]. Two grams of CTAB were dissolved in 1000 mL of ultrapure water and 9 mL of NaOH (2 M) and stirred (at a rotational speed of 250 min -1 ) for 20 min at 60°C.…”

Section: Methodsmentioning

confidence: 99%

Nanoporous silica nanoparticles with spherical and anisotropic shape as fillers in dental composite materials

et al. 2014

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The objective of this study was to test whether nanoporous silica nanoparticles can be employed as fillers in dental composite materials to improve their mechanical properties. These nanoporous silica nanoparticles were synthesized using sol-gel methods, in part modified by silanization, and thoroughly characterized. The nanoporous nanoparticles were added to dental resins to form nanocomposites (resins impregnated with nanoparticles) and hybrid composites (containing in addition conventional microfillers). The incorporation of these nano porous nanoparticles in dental resins or composites was characterized by investigation of the complex viscosity and double bond conversion as well as by determination of flexural strength and Young's modulus. The dispersion of the nanofillers was examined by SEM and EDX imaging of fracture surfaces. Incorporation of small contents (1-3 wt%) of unmodified nanoporous particles leads to improved mechanical properties. However, the incorporation of larger contents results in particle agglomeration and declining mechanical properties. This effect is less pronounced when the surface of the particles is modified with methacrylate residues, resulting in a lower agglomeration tendency and a more homogeneous filler dispersion. Surface properties and, concomitantly, dispersibility of the nanoparticles have a strong influence on mechanical properties. But the incorporation of nanoporous instead of solid nanoparticles into dental composite materials is indeed a possibility to improve the mechanical behavior. However, modification of the surface is necessary and the key to achieving uniform dispersion and, thereby, improving mechanical properties.

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One‐Pot Synthesis of Functional Helicoidal Hybrid Organic–Inorganic Nanofibers with Periodically Organized Mesoporosity

Cited by 57 publications

References 68 publications

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

The Synthesis of Chiral Periodic Organosilica Materials with Ultrasmall Mesopores

Nanoporous silica nanoparticles with spherical and anisotropic shape as fillers in dental composite materials

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