One-Pot Synthesis of (Guaiazulen-1-yl)furan Derivatives from Guaiazulene and 1,4-Diaryl-2-butene-1,4-diones

Synthesis of Coumarino[4,3-b]pyran-4-one Derivatives

“…近年来, 我们以含氧稠杂环化合物为研究对象, 先 后合成了具有潜在生物活性的含吡喃 [9] 、呋喃 [10] 、香豆 素 [11] 等结构单元的稠杂环化合物. 基于香豆素类化合 物良好的化学及生物活性, 本文以 4-羟基-3-乙酰基香 …”

Efficient One-Pot Synthesis of 1,4-Dihydropyridino[3,2-c]coumarins

“…其中吡啶并香豆素类化合物由于具有抑制 单胺氧化酶 [5] 、抗肿瘤 [6] 、止痛 [7] 、抗菌 [8] [9] (结构式 A), 二 氢喹啉并[3,2-c]香豆素 [10] (结构式 B), 具有抗肿瘤活性 的四氢喹啉并[3,2-c]香豆素 [11] (结构式 C)等, 成为香豆 素类化合物研究领域中的一个热点. 最近, 我们以稠杂环化合物为研究对象, 先后合成 了具有潜在生物活性的含吡啶 [12] 、吡喃 [13] 、呋喃 [14] 、香 豆素 [15] [17] 受到关注, 但在碘作用下的该类反应报道不 多 [18] . 另外, 在此类反应中得到相关二氢吡啶类结构的 鲜有报道 [19] .…”

Synthesis of 2-Aminobutene-1,4-Diones by Gold-Catalysed Three-Component Coupling Reactions

“…[1][2][3][4] Additionally, these 2-aminobutene-1,4-diones can also serve as useful tools for constructing heterocyclic compounds in organic synthesis containing, for example, pyrrole, hydrazine, furan and cyclopentenone moieties. [5][6][7][8] As a consequence, various methods for their preparation have been reported previously, for example, conjugate addition of diaroylacetylenes or sulfur ylides to aryl azides, 9,10 using α,β-unsaturated γ-dicarbonyl or acetophenones with amines, 11,12 reaction of pyridinium bromides and primary aromatic amines with phenylglyoxal or ethyl glyoxalate 13 and other ways. 14,15 Recently, Wu and co-workers developed an efficient Cu-catalysed tandem reaction to synthesise 2-aminobutene-1,4-diones in good yields, but a long reaction time is needed.…”