One-pot synthesis of hydrophilic flower-shaped iron oxide nanoclusters (IONCs) based ferrofluids for magnetic fluid hyperthermia applications

Abstract

Herein, flower-shaped hydrophilic superparamagnetic iron oxide nanoclusters (IONCs) are synthesized via onepot thermolysis of iron acetylacetonate using triethanolamine (TEA) and diethylene glycol (DEG)/tetraethylene glycol (TTEG) mixtures at 9:1, 8:2 and 7:3 (v/v) ratios. The as-prepared 24-29 nm sized IONCs have displayed (i) saturation magnetization (Ms) values of~68-78 emu/g, (ii) hydrodynamic diameters of~95-192 nm and (iii) zeta potential values of +46 to +65 mV. Due to relatively high magnetization and water solubility, IONCs (prepared using 8:2 TEA:DEG, and 8:2 & 7:3 TEA:TTEG ratios) based aqueous ferrofluids i.e. NCAFF-1, NCAFF-2, and NCAFF-3 are investigated by calorimetric magnetic fluid hyperthermia (MFH) at 0.5-8 mg/ml concentrations by exposing them to the alternating magnetic fields (AMFs, H*f~2.4-9.9 GA m −1 s −1). The NCAFF-3 has demonstrated excellent time dependent temperature rise (42°C within 0.7-9.7 min) as compared to the NCAFF-1 and NCAFF-2. Moreover, the NCAFF-3 at 0.5 mg/ml concentration has exhibited enhanced heating efficacies with specific absorption rate (SAR) and intrinsic loss power (ILP) values of 142.4-909.4 W/g Fe and 4.2-14.7 nHm 2 /kg, respectively. Furthermore, the NCAFF-3 has presented better cytocompatibility, and substantially reduced proliferation capacity of HepG2 cancer cells in in vitro MFH studies. Thus, the IONCs based ferrofluids (NCAFF-3) are very promising candidates for MFH therapeutics applications.

Atom Transfer Radical Polymerization of 2-Isopropenyl-2-Oxazoline in Solution and from the Surface of Carbonyl Iron Particles toward Fabrication of a Cytocompatible Magneto-Responsive Hybrid Filler

“…Overall, it can be stated that the shear stress values, representing the vascular sealing capability, are high enough to provide the embolization of veins. The tunability of the rheological properties was confirmed, and the values of the yield stress indicate that the investigated smart system could be promising for the application as a temporary vascular embolization agent. − …”

Insights into the Magnetic Properties of Single-Core and Multicore Magnetite and Manganese-Doped Magnetite Nanoparticles

“…15 Moreover, magnetic interactions between the cores can increase or decrease the heating efficacies. 15,33,46,47 In this context, the observed differences in the SAR values of Fe 3 O 4 -50-N and to Fe 3 O 4 -60 samples can be related to the degree of fusion between the cores inside the particles (exchange interactions) and the surface anisotropy (dipolar interparticle interactions). The Fe 3 O 4 -50-N sample presents a larger M S value and larger crystal domains than those corresponding to the Fe 3 O 4 -60 sample, but probably dipolar interactions between the primary particles, which produce this particular microstructure, drastically decrease the total anisotropy of the system and heat generation.…”

Inorganic nanocarriers for siRNA delivery for cancer treatments

“…Among them, spinel ferrites possess attractive superparamagnetic characteristics, with magnetic and heat stimuliresponsiveness, for use in imaging and therapeutics [48,49]. For instance, superparamagnetic iron oxide nanoparticles (SPIOs) have been utilized as good: (i) T2 contrast agents for magnetic resonance imaging (MRI) [50][51][52][53], and (ii) heating agents in many magnetic hyperthermia cancer treatments [54][55][56][57][58]. Besides, magnetic/heat-based stimuli responsiveness in SPIOs is employed in transport and delivery of anti-cancer drugs and TpRNAs.…”