One-pot synthesis of natural amine-modified biocompatible carbon quantum dots with antibacterial activity

Gagić, Milica; Kočiová, Silvia; Šmerková, Kristýna; Michalkova, Hana; Šetka, Milena; Švec, P; Přibyl, Jan; Másilko, Jiří; Bálková, Radka; Heger, Zbyněk; Richtera, Lukáš; Adam, Vojtěch; Milosavljević, Vedran

doi:10.1016/j.jcis.2020.06.125

Cited by 56 publications

(41 citation statements)

References 81 publications

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“…Gagic et al reported that, due to the membrane integrity being damaged, almost no Staphylococcus aureus was observed after treatment with 2× MIC of amine-modified carbon dots, while most of the Staphylococcus aureus was killed by treatment with carbon dots at 1× MIC. 18 This result suggested that the cell membrane integrity was destroyed and the viability of Pseudomonas fragi was reduced after being treated with the onion carbon dots.…”

Section: Resultsmentioning

confidence: 99%

“…39 The neutral charged carbon dots with small size could enter the cells without limitation, and destroyed the permeation barrier of the cell membrane/wall, leaking the intracellular material, and leading to the death of bacteria. 18…”

Section: Resultsmentioning

confidence: 99%

“…17 Four different natural amine-functionalized carbon dots synthesized using citric acid and biogenic amines (histamine, putrescine, cadaverine and spermine) exhibited antimicrobial properties against Escherichia coli , Klebsiella pneumonia , and Staphylococcus aureus through the destabilization of the bacterial membrane caused by oxidative stress. 18 Positively charged carbon dots prepared from ammonium carbonate, diethylamine, and chloroform showed strong electrostatic interactions with negatively charged bacteria, and exhibited antimicrobial ability by destroying the bacterial cell walls/membranes. 19 Spermidine-capped fluorescent carbon quantum dots exhibited promising antibacterial characteristics against non-multidrug-resistant and multidrug-resistant bacteria by damaging the bacterial membrane.…”

Section: Introductionmentioning

confidence: 99%

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Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage

Cheng

Tan

2022

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage

Cheng

Tan

2022

Food Funct.

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“…In turn, utilization of nitrogen-containing polymers and quaternary ammonium compounds instead of alkylamines enhances the antibacterial properties of the resulting CDs only toward Grampositive bacteria and still insufficient toward Gram-negative bacteria [13,15,[53][54][55]. The highest antimicrobial properties towards both bacteria was exhibited only by CDs synthesized from several nitrogen-containing components [14,56]. In comparison with discussed above approaches, covalent grafting of TAA to CDs provides low MIC values for both Gram-positive and negative bacteria combined with simple modification procedure.…”

Section: Antimicrobial Properties and Cytotoxicity Towards Staphyloco...mentioning

confidence: 99%

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Sviridova

Barras

Plotnikov

et al. 2021

Preprint

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In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria. CDs were modified by novel diazonium salts bearing tetraalkylammonium moieties (TAA) with different alkyl chains (C2, C4, C9, C12) for the optimization of antibacterial activity. The functionalized CDs were characterized by X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV-vis) absorption spectrophotometry and fluorescence spectroscopy to confirm the covalent binding of TAA onto the CDs’ surface. Variation of the alkyl chain allows to reach the strongest antibacterial effect for CDs-C9 towards Gram-positive S. aureus (MIC 3.09±1.10 µg mL-1) and Gram-negative E. coli (MIC 7.93±0.17 µg mL-1) bacteria. In addition, the antibiofilm properties of the CDs-C9 were assessed; full biofilm inhibition was achieved after 6 h (64 µg mL-1) and 2 h (128 µg mL-1) treatment for S. aureus biofilm and >60% suppression of biofilm mass after 6 h (128 µg mL-1) for E. coli biofilm. CDs-C9 demonstrated good biocompatibility on mouse fibroblast (NIH/3T3), HeLa and U-87 MG cell lines for concentrations up to 256 µg mL-1. Collectively, our work highlights the correlation between the surface chemistry of CDs and their antimicrobial performance.

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“…In addition to the advantages related to the particle size and wavelength-dependent luminescence characterizing quantum dots, fluorescent CDs also have high light stability and present no light scintillation phenomena. Their surface is easily functionalized and modified, and the preparation materials are widely available [4][5][6]. Wang et al evaluated the toxicity of CDs and showed that they do not cause any abnormalities or damage to tissues and organs [7].…”

Section: Introductionmentioning

confidence: 99%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

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One-pot synthesis of natural amine-modified biocompatible carbon quantum dots with antibacterial activity

Cited by 56 publications

References 81 publications

Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage

Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

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