One-pot synthesis of new benzo[4,5]imidazo[2,1-b]pyrimido[4,5-d][1,3] thiazine-2,4(3H)-dione and benzo[4,5]imidazo[2,1-b][1,3]thiazin-4-one derivatives as new anti-cancer components

Batooie, Nasim; Khodaei, Mohammad Mehdi; Bahrami, Kiumars; Miraghaee, Seyyed Shahram; Hosseinzadeh, Nouraddin; Sajadimajd, Soraya

doi:10.1016/j.molstruc.2022.134037

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Hence, flavone A may be employed as a natural therapeutic molecule for treating pancreatic cancer. A synthesized novel benzo[4,5]imidazo[2,1- b ]pyrimido[4,5- d ][ 1 , 3 ]thiazine-2,4(3H)-diones and benzo[4,5]imidazo[2,1- b ][ 1 , 3 ]thiazin-4-ones showed efficient anti-cancer activity towards A431, Panc1, and PC3 [ 111 ]. These compounds exhibited IC 50 values of 21.6 and 31.9 µM against Panc1 compared to etoposide (25.2 µM).…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Kumar

et al. 2023

Biomedicines

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Cancer is a significant challenge for effective treatment due to its complex mechanism, different progressing stages, and lack of adequate procedures for screening and identification. Pancreatic cancer is typically identified in its advanced progression phase with a low survival of ~5 years. Among cancers, pancreatic cancer is also considered a high mortality-causing casualty over other accidental or disease-based mortality, and it is ranked seventh among all mortality-associated cancers globally. Henceforth, developing diagnostic procedures for its early detection, understanding pancreatic cancer-linked mechanisms, and various therapeutic strategies are crucial. This review describes the recent development in pancreatic cancer progression, mechanisms, and therapeutic approaches, including molecular techniques and biomedicines for effectively treating cancer.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Kumar

et al. 2023

Biomedicines

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“…In this trend, Xu et al fabricated several benzimidazole-imidazole compounds as autophagic flux inhibitors, exhibiting significant capability against human TNBC. [97] Compound 50 (Figure 15 In a very recent study, an effectual one-pot procedure has been designed for the production of diverse new benzo [4,5]imidazo[2,1-b]pyrimido[4,5-d][1,3]thiazine-2,4(3H)-diones and benzo [4,5]imidazo[2,1-b][1,3]thiazin-4-ones through the three-component reaction of CÀ H acid derivatives, benzaldehydes and 2-mercaptobenzimidazole employing hexyltriphenylphosphonium bromide (HTPB) as an eco-friendly catalyst and solvent, [98] exploring their anticancer ability towards various cancer cell lines, i. e., A431, PC-3 (prostate carcinoma), and Panc1. Compound 51 (Figure 16), among the synthesized compounds, unveiled the best anticancer properties against the cancer cells mentioned above, with a measured IC 50 value less than etoposide.…”

Section: Miscellaneous Anti-cancer Activitiesmentioning

confidence: 99%

Recent Advances in the Anticancer Applications of Benzimidazole Derivatives

Mavvaji,

Akkoc

2023

ChemistrySelect

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Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human well‐being. Hence, the design and development of modern protocols to cure diverse kinds of cancer seem highly necessary. On the other hand, benzimidazole, as an essential pharmacophore, exhibits various biological and therapeutic potency. This compound is well‐known for its pharmaceutical features, including antifungal, antiviral, antibacterial, and anticancer activities. Therefore, benzimidazole derivatives have played an essential role due to their outstanding anticancer capability, apoptotic effect, and inhibitory potential. In recent decades, numerous anticancer drug types of research have been concentrated on finding new and practical strategies for employing benzimidazole‐based compounds. This review focuses on the latest advancements and methodologies for exploiting various benzimidazole‐bearing compounds for the treatment of varied sorts of cancer, considering the mechanism of their function against cancer cell lines.

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“…In this respect, the condensed azetothiazine is a key fragment in the structure of cephalosporins (Figure 1) [2,3]. In addition, promising antiviral and antimicrobial agent PD404182 [4,5], antituberculosis [6], anticancer [7][8][9], and anti-inflammatory [10] agents were found among 1,3-thiazine condensed derivatives. They proved to be agrochemical growth regulators in Cucumis sativus cultures [11].…”

Section: Introductionmentioning

confidence: 99%

Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate

Vinogradov,

Izmest'ev,

Kravchenko

et al. 2023

Journal of Heterocyclic Chem

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A method for the regioselective synthesis of imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazine derivatives has been developed by the reaction of imidazotriazinethiones with ethyl phenylpropiolate upon treatment with potassium carbonate or sodium methoxide in methanol. The synthesis was accomplished by Michael‐type addition of the imidazotriazinethiones to the triple bond of ethyl phenylpropiolate followed by subsequent intramolecular cyclization.

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One-pot synthesis of new benzo[4,5]imidazo[2,1-b]pyrimido[4,5-d][1,3] thiazine-2,4(3H)-dione and benzo[4,5]imidazo[2,1-b][1,3]thiazin-4-one derivatives as new anti-cancer components

Cited by 6 publications

References 36 publications

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Recent Advances in the Anticancer Applications of Benzimidazole Derivatives

Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate

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