One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions

Novel and rapid approach for benzanthrone synthesis: BBr3-promoted annulation of 8-aryl-1-naphthoic acid derivatives

“…Owing to the same characteristic carbonyl junction between two aromatic rings, oxoglaucine ( 10 ), a representative oxoaporphine alkaloid, could be simply synthesized by applying this strategy with high regioselectivity and a total yield of 70%. This is different from classical synthetic approaches 40–43 to oxoaporphines, which highly depend on oxidation or dehydrogenation steps to access the carbonyl group or biphenyl structure.…”

A Copper‐Catalyzed [5+1] Cycloaddition of Terminal Alkynes with Diazo Esters through a Tandem 1,5‐H‐Shift Cyclization

“…As a pair of tautomeric structures, 1-dihydronaphthalenone A and 1-naphthalenol B are widely present in various natural products and pharmaceutical medicines. [1] As shown in Figure 1, Lysicamine, holding a significant antioxidant capacity, is obtained from G. hispida; [2] Oxoglaucine, isolated from Glaucium flavum, possesses good anti-inflammation activities; [3] Gossypol, a natural product isolated from cottonseeds and roots, has been studied as an anticancer agent; [4] Rifamycins B and its family chemicals had been applied in the clinic for the treatment of tuberculosis, leprosy, and mycobacterial infections for decades. [5] Therefore, discovering new synthetic methods to directly construct the pivotal 1-dihydronaphthalenone skeleton and its derivatives is an important goal in the fields of synthetic organic chemistry and medicinal chemistry.…”

Arene‐Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via Glucose Metabolism Reprogramming

“…[32][33][34][35] Oxoaporphine is an active ingredient from the traditional Chinese medicines with chelated N,O donors and certain anticancer activity. [36] Oxoaporphine metal complexes exhibited great potential as anticancer agents with multi-targeting and multi-action mechanisms. [37][38][39] To discover more potential arene-Ru II /Os II complexes for reversing the disadvantages of fasting in combination with chemotherapy, we propose a new strategy to combine Met.…”