One-pot synthesis of polyvinyl alcohol/silica composite microspheres in a surfactant-free system for biomedical applications

Chen, Feng-Wu; Teng, Sheng; Xia, Shuhui; Wang, Peng; Pan, Guoqing

doi:10.1007/s10971-016-4118-9

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…As shown in Figure 3(a), both the CS and CS-SiO 2 hybrid microspheres had almost exactly the same weight loss steps. The large weight loss occurring in the region of 200-600°C was probably associated with the decomposition of CS as well as the progressive polycondensation and dehydration of silica xerogel [23], corresponding to the strong exothermic peak in the DSC curves (Figure 3(b)). After deducting the residual amount of the pure CS microspheres (~3 wt%), the SiO 2 contents of the CS-20%SiO 2 and CS-40%SiO 2 hybrid microspheres were determined from the TG curves Journal of Nanomaterials to be about 13 wt% and 23 wt%, respectively, lower than their theoretical values.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Niu

Teng

Zhou

et al. 2019

Journal of Nanomaterials

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Chitosan-silica (CS-SiO2) hybrid microspheres were prepared through the combined process of sol-gel and emulsification-crosslinking. Their composition, morphology, in vitro bioactivity, and drug release behavior were investigated. The results showed that, when 20 wt% SiO2 was incorporated, the as-prepared CS-SiO2 hybrid microspheres exhibited a regular spherical shape, a high dispersity, and a uniform microstructure. Their average particle diameter was determined to be about 24.0 μm. The in situ deposited inorganic phase of the hybrid microspheres was identified as amorphous SiO2, and its actual content was determined by the TG analysis. As compared with the pure chitosan microspheres, the CS-SiO2 hybrid microspheres displayed a greatly improved in vitro bioactivity. Vancomycin hydrochloride (VH) was selected as a model drug. It was demonstrated that the CS-SiO2 hybrid microspheres presented a good capacity for both loading and sustained release of VH. Moreover, the increase of the SiO2 content efficiently slowed down the drug release rate of the CS-SiO2 hybrid microspheres.

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Section: Resultsmentioning

confidence: 99%