One‐pot synthesis of primary 1‐aminophosphonates: Coupling reaction of carbonyl compounds, hexamethyldisilazane, and diethyl phosphite catalyzed by Al(OTf)₃

Abstract

Al(OTf) 3

An eco-friendly procedure for the efficient synthesis of diethyl α-aminophosphonates in aqueous media using natural acids as a catalyst

“…One-pot Kabachnik-Fields reaction can be promoted by acidic or basic catalysts, microwave irradiation, or by heating [30]. Several Lewis acid catalysts, such as InC l3 [31], LiClO 4 [32,33] [37], FeCl 3 [38], YbCl 3 [39], In(OTf) 3 [40], Ce(OTf) 4 [41], Al(OTf) 3 [42], CAN [43], TaCl 5 -SiO 2 [44], and SmI 2 [45] solid acids (montmorillonite KSF, silica sulfuric acid, Amberlyst-15, and Amberlite-IR 120 [46], base catalysts such as CaCl 2 and PPh 3 and other catalysts such as ZnO, TiO 2 , tosyl chloride, and mesoporous aluminosilicate nanocage [47] have also been used to promote this reaction.…”

Dicationic ionic liquids as recyclable catalysts for one‐pot solvent‐free synthesis of α‐aminophosphonates

“…Therefore, the synthesis of α-aminophosphonates has received considerable attention and substantial progress has been made to develop more efficient methods for synthesis of these compounds [3,4]. Lewis acids [5][6][7][8][9], Brønsted acids [10][11][12], solid acids [13,14], rare metal salts [15], or organo compounds [16,17] have been investigated as the catalysts for the synthesis of α-aminophosphonates over recent decades. However, the search for new, readily available, and green catalysts is still being actively pursued.…”

SO3H‐functionalized ionic liquids catalyzed the synthesis of α‐aminophosphonates in aqueous media

“…Some synthetic methods including one-pot synthesis of α-aminophosphonates have been explored in the presence of Lewis acids [2][3][4][5][6], Brønsted acids [7][8], solid acids [9][10], rare metal salts [11], or metal oxides [12] over recent decades.…”