One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine

We have successfully synthesized piperidine and pyrrolidine derivatives by electroreductive cyclization using readily available imine and terminal dihaloalkanes in a flow microreactor. Reduction of the substrate imine on the cathode proceeded efficiently due to the large specific surface area of the microreactor. This method provided target compounds in good yields compared to a conventional batch-type reaction. Furthermore, piperidine and pyrrolidine derivatives could be obtained on preparative scale by continuous electrolysis for approximately 1 hour.

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One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine

Abstract: Concise and accessible approaches to pyrrolidine-2-ones were studied. The synthesis involves the conversion of erythruronolactone to pyrrolidine-2-ones in good yields.

Cited by 3 publications

References 18 publications

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Retracted: One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine

Synthesis of piperidine and pyrrolidine derivatives by electroreductive cyclization of imine with terminal dihaloalkanes in a flow microreactor

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