One-pot synthesis of quinazolin-4(3H)-ones and2,3-dihydroquinazolin-4(1H)-ones utilizingN-(2-aminobenzoyl)benzotriazoles

Abstract

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3 H)ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3 H)-ones, and 2,3-dihydroquinazolin-4(1 H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.

N-(2-Aminobenzoyl)benzotriazole Mediated Synthesis of 3- Acyl-2-alkyl(aryl)-4-hydroxyquinolines and 3-Acylamino-4(3H) quinazolinones

“…N -(2-aminobenzoyl) benzotriazole compounds, which are derivatives of N -acyl benzotriazole, have many benefits such as being crystalline, dissolving in many organic solvents, not absorbing moisture, and being stable. Besides, these compounds are used as starting materials in the synthesis of anthranylesters and anthranylthioesters [ 34 ], anthranilamides [ 35 ] and some heterocyclic compounds [ 36 – 38 ].…”