One-pot Synthesis of Quinazolinone and Benzamide Derivatives Using SBA-Pr-SO3H as a Nanoporous Heterogeneous Acid Catalyst

Nahad, Monireh Shakiba; Ziarani, Ghodsi Mohammadi

doi:10.13005/ojc/290443

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Using a reported procedure, N-methyl isatoic anhydride 3; the starting material; was refluxed for 4 hrs with paminoacetophenone in glacial acetic acid to produce the benzamide intermediate 4 [21][22][23]. Benzamide 4 is a versatile intermediate for the synthesis of different quinazolinones derivatives [26][27][28]. The benzamide intermediate 4 was identified by matching its M.p.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Emam

Kothayer²,

Ibrahim³

et al. 2022

Egypt. J. Chem.

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Antibacterial agents structurally based on quinazolin-4-one pharmacophore, have been designed and synthesized. Where the targeted compounds 5a, c and 6a-c were in vitro screened against three gram positive and three gram negative bacteria strains compared to ciprofloxacin as reference drug. Most of compounds had moderate antibacterial activity while compound 5c showed the most significant activity and could be considered as a new lead compound for antibacterial drug design.

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Section: Chemistrymentioning

confidence: 99%

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Emam

Kothayer²,

Ibrahim³

et al. 2022

Egypt. J. Chem.

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Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine

Ranjbar‐Karimi

Davodian

Mehrabi

2017

Journal of Heterocyclic Chem

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A new series of 4‐hetroaryl substituted quinazolines were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2‐substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4‐position of pyridine ring by the oxygen site (O‐centered nucleophile) of quinazolinone. The structures of all the compounds were confirmed by IR, 1H NMR, 19F NMR, and 13C NMR spectroscopy as well as elemental analysis.

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Silica-based nanocatalysts in the C C and C-heteroatom bond forming cascade reactions for the synthesis of biologically active heterocyclic scaffolds

et al. 2017

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One-pot Synthesis of Quinazolinone and Benzamide Derivatives Using SBA-Pr-SO3H as a Nanoporous Heterogeneous Acid Catalyst

Cited by 6 publications

References 7 publications

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine

Silica-based nanocatalysts in the C C and C-heteroatom bond forming cascade reactions for the synthesis of biologically active heterocyclic scaffolds

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