One-Pot Synthesis of Reduced Graphene Oxide/Metal (Oxide) Composites

Wu, Xu; Xing, Yuqian; Pierce, David T.; Zhao, Julia Xiaojun

doi:10.1021/acsami.7b12539

Cited by 57 publications

(32 citation statements)

References 59 publications

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“…Furthermore, Pt ions are easily absorbed uniformly by GO due to the presence of abundant hydroxyl and carboxyl functional groups. Wu et al [27] fabricated reduced graphene oxide (RGO)/metal (oxide) composites using glucose as the reducing agent and the stabilizer. The developed composite nanomaterials show excellent electrode catalyst to simultaneous electrochemical analysis of l -ascorbic acid, dopamine, and uric acid.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide–Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer

et al. 2019

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Metal nanoparticles and the combination of metal nanoparticles with graphene oxide are widely used in environmental, agriculture, textile, and therapeutic applications. The effect of graphene oxide–green platinum nanoparticles (GO-PtNPs) on human prostate cancer cells (LNCaP) is unclear. Therefore, this study aimed to synthesize a nanocomposite of GO-PtNPs and evaluate their effect on prostate cancer cells. Herein, we synthesized GO-PtNPs using vanillin and characterized GO-PtNPs. GO-PtNP cytotoxicity in LNCaP cells was demonstrated by measuring cell viability and proliferation. Both decreased in a dose-dependent manner compared to that by GO or PtNPs alone. GO-PtNP cytotoxicity was confirmed by increased lactate dehydrogenase release and membrane integrity loss. Oxidative stress induced by GO-PtNPs increased malondialdehyde, nitric oxide, and protein carbonyl contents. The effective reactive oxygen species generation impaired the cellular redox balance and eventually impaired mitochondria by decreasing the membrane potential and ATP level. The cytotoxicity to LNCaP cells was correlated with increased expression of proapoptotic genes (p53, p21, Bax, Bak, caspase 9, and caspase 3) and decreased levels of antiapoptotic genes (Bcl2 and Bcl-xl). Activation of the key regulators p53 and p21 inhibited the cyclin-dependent kinases Cdk2 and Cdk4, suggesting that p53 and p21 activation in GO-PtNP-treated cells caused genotoxic stress and apoptosis. The increased expression of genes involved in cell cycle arrest and DNA damage and repair, and increased levels of 8-oxo-deoxyguanosine and 8-oxoguanine suggested that GO-PtNPs potentially induce oxidative damage to DNA. Thus, GO-PtNPs are both cytotoxic and genotoxic. LNCaP cells appear to be more susceptible to GO-PtNPs than to GO or PtNPs. Therefore, GO-PtNPs have potential as an alternate and effective cancer therapeutic agent. Finally, this work shows that the combination of graphene oxide with platinum nanoparticles opens new perspectives in cancer therapy. However further detailed mechanistic studies are required to elucidate the molecular mechanism of GO-PtNPs induced cytotoxicity in prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Graphene Oxide–Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer

et al. 2019

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“…Preparation of reduced GOs (r-GOs) can be achieved to solve poor conductivity of GOs by treating them with different reducing agents such as hydroquinone, diazene (N 2 H 2 ), hydrazine(N 2 H 4 ), sodium borohydride(NaBH 4 ), sodium hydroxide (NaOH), sodium sulfide (Na 2 S), sodium bisulfate (NaHSO 3 ), ascorbic acid (C 6 H 8 O 6 ), and hydroiodic acid (HI) [ 34 , 35 ]. GOs have been reported in preparation for a variety of composite materials [ 36 ] such as metal composites [ 37 ], various polymers, hydrogels [ 38 ], and cryogels [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene Aerogels for In Situ Synthesis of Conductive Poly(para-phenylenediamine) Polymers, and Their Sensor Application

2020

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In this study, macroporous graphene aerogels (GAs) were synthesized by chemical reduction of graphene oxide sheets and were used as a support material for in situ synthesis of conductive poly(para-phenylenediamine) (p(p-PDA)). The in situ synthesis of p(p-PDA) in GA was carried out by using a simple oxidation polymerization technique. Moreover, the prepared conductive p(p-PDA) polymers in the networks of GAs were doped with various types of acids such as hydrochloric acid (HCl), nitric acid (HNO3), sulfuric acid (H2SO4), phosphoric acid (H3PO4), respectively. The prepared GA and different acid-doped forms as GA/p(p-PDA) composites were characterized by FT-IR, TGA, and conductivity measurements. The observed FT-IR peaks at 1574 cm−1, and 1491 cm−1, for stretching deformations of quinone and benzene, respectively, confirmed the in situ synthesis of P(p-PDA) polymers within GAs. The conductivity of GAs with 2.17 × 10−4 ± 3.15 × 10−5 S·cm−1 has experienced an approximately 250-fold increase to 5.16 × 10−2 ± 2.72 × 10−3 S·cm−1 after in situ synthesis of p(p-PDA) polymers and with HCl doping. Conductivity values for different types of acid-doped GA/p(p-PDA) composites were compared with the bare p(p-PDA) and their undoped forms. Moreover, the changes in the conductivity of GA and GA/p(p-PDA) composites upon CO2 gas exposure were compared and their sensory potential in terms of response and sensitivity, along with reusability in CO2 detection, were evaluated.

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“…The presence of epoxide, carbonyl, carboxyl, and hydroxyl groups on GO nanosheets enables facile chemical and biological modification, obtaining GO as a biological substitute in the biomedical field [29,30,31]. Extremely, GO has enhanced antibacterial activity due to the physical damages occurred upon direct contact to bacterial membranes by sharp edges of GO nanosheets [32], which has motivated researchers to carry out regarding the use of GO in an extensive range of biomedical applications including antibacterial materials, bioimaging, biosensors, tissue-engineering scaffoldsand gene/drug delivery [33,34,35].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential Wound Dressing Application

Yang

Zhang

2019

IJMS

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In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free CS/PVA nanofibers were obtained and GO nanosheets, shaping spindle and spherical, were partially embedded into nanofibers. Besides, the antibiotic drugs were effectively loaded into the nanofibers and part of which were absorbed into GO nanosheets. Intriguingly, the release of the drug absorbed in GO nanosheets regulated the drug release profile trend, avoiding the “burst” release of drug at the release initial stage, and the addition of GO slightly improved the drug release ratio. Nanofibrous membranes showed the significantly enhanced antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis after the addition of antibiotic drug. Moreover, the drug-loaded nanofibrous membranes exhibited excellent cytocompatibility with Melanoma cells, indicative to the great potential potential for applications in wound dressing.

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One-Pot Synthesis of Reduced Graphene Oxide/Metal (Oxide) Composites

Cited by 57 publications

References 59 publications

Graphene Oxide–Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer

Graphene Oxide–Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer

Graphene Aerogels for In Situ Synthesis of Conductive Poly(para-phenylenediamine) Polymers, and Their Sensor Application

Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential Wound Dressing Application

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